2,2-bis(hydroxymethyl)hexadecanol | 97014-26-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-bis(hydroxymethyl)hexadecanol
• 英文别名: 2,2-dihydroxymethyl-hexadecanol；2-hydroxymethyl-2-tetradecyl-propane-1,3-diol；2-(hydroxymethyl)-2-tetradecylpropane-1,3-diol
• CAS: 97014-26-1
• 化学式: C₁₈H₃₈O₃
• 分子量: 302.498
• InChiKey: BDIHTLOLBRTRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-bis(hydroxymethyl)hexadecanol 在 sodium hydroxide 、 三甲基氨基磺酸 、 二正丁基氧化锡 、 copper(II) sulfate 、 mercury dibromide 、 mercury(II) oxide 作用下， 以 四氢呋喃 、 甲醇 、 1,2-二氯乙烷 为溶剂， 反应 38.0h， 生成 2-tetradecyl-1,2,3-tris[(3-O-sulfo-β-D-galactopyranosyl)oxy]propane trisodium salt
  参考文献：
  名称：

  Synthetic Studies on Selectin Ligands/Inhibitors: Synthesis and Biological Activity of the Sulfated and Phosphorylated Multivalent β-D-Galactopyranosides Containing Fatty Alkyl Residues

  摘要：

  Ten sulfated and three phosphorylated beta-D-galactopyranoside dimers and one sulfated beta-D-galactopyranoside trimer containing fatty alkyl residues in place of ceramide have been synthesized. The coupling of 2,3,4,6-tetra-0-acetyl-alpha-D-galactopyranosyl bromide (2) with branched fatty alkyl diols and a triol (1a-1j) using mercury bromide as an activating agent gave the corresponding parent glycolipids (4a-4j) in good yields. Regioselective sulfation of these parent glycolipids through the dibutylstannylene acetals produced the target sulfated glycolipids, 3-sulfate (5a-5j) while stepwise phosphorylation with dibenzyloxy(diisopropylamino)phosphine gave the phosphorylated glycolipids, 3,4-bisphosphate (9e, g, i). The synthetic glycolipids were assayed for their ability to block the adhesion of HL-60 cells to immobilized P-, L- and E-selectin.

  DOI：

  10.1080/07328309808002333
• 作为产物：
  描述：

  十六醛 在 盐酸 、 甲醇 、 硫酸 作用下， 生成 2,2-bis(hydroxymethyl)hexadecanol
  参考文献：
  名称：

  Olsen,S. et al., Justus Liebigs Annalen der Chemie, 1962, vol. 654, p. 198 - 209

  摘要：

  DOI：

文献信息

• Synthesis and Antibacterial Properties of Novel Hydrolyzable Cationic Amphiphiles. Incorporation of Multiple Head Groups Leads to Impressive Antibacterial Activity
  作者：Jayanta Haldar、Paturu Kondaiah、Santanu Bhattacharya

  DOI：10.1021/jm049106l

  日期：2005.6.1

  (CPB). The killing effects of the new single-headed amphiphiles (T1 and P1) were lower than those of CTAB and CPB, but with an increase in the number of headgroups in the amphiphiles, the killing effects increased for both sets of compounds. It was found that amphiphiles with triple headgroups (T3 and P3) were most active among all the amphiphiles, whereas amphiphile P1 had a very poor killing effect

  合成了两套带有一个，两个和三个三甲基铵头基（T1，T2和T3）和吡啶鎓头基（P1，P2和P3）的新型多头阳离子两亲物，并测试了它们对革兰氏阳性和革兰氏阴性菌的抗菌活性。革兰氏阴性细菌。这些两亲物中的多阳离子头基通过可裂解的酯型键共价连接。将结果与已知的表面活性，不可水解的化合物十六​​烷基三甲基溴化铵（CTAB）和十六烷基溴化吡啶鎓（CPB）的结果进行了比较。新的单头两亲物（T1和P1）的杀伤作用低于CTAB和CPB，但随着两亲物中头基数目的增加，两组化合物的杀伤作用均增加。发现在所有两亲中，具有三个头基的两亲（T3和P3）最活跃，而两亲P1对这两种细菌的​​杀灭效果都非常差。与三甲基铵对应物相比，多头吡啶鎓两亲物活性更高。用多头两亲物杀死细菌所需的时间明显少于单头两亲物。由于存在可裂解的酯部分，这些新的两亲物在生理条件下自发水解。这种特性使它们易于代谢，因此有可能成为食品和身体表面的优质
• RESIN FOR PRINTING INK AND PRINTING INK
  申请人：TOYO INK MFG. CO., LTD.

  公开号：EP1160259A1

  公开（公告）日：2001-12-05

  The invention discloses a resin for a printing ink which comprises an ester-modified hydrocarbon resin, which is ester-modified with a long chain aliphatic alcohol, having a melting point of not lower than 100ºC, wherein the ester-modified hydrocarbon resin has not higher than 100ºC at a clouding temperature as the solubility in a hydrocarbon solvent having an aromatic component of not greater than 3% byweight, comprising a naphthene hydrocarbon and/or a paraffin hydrocarbon and having a boiling point of not lower than 200ºC. The invention provides the excellent properties in the suitable emulsification property, the misting property, set and the drying property as a printing ink which is prepared using the hydrocarbon solvent.

  本发明公开了一种用于印刷油墨的树脂，该树脂由酯类改性碳氢化合物树脂组成，该树脂由长链脂肪醇酯类改性，熔点不低于 100ºC，其中酯类改性碳氢化合物树脂在烃类溶剂中的混浊温度不高于 100ºC，该烃类溶剂中的芳香族成分不大于 3%（重量百分比），该烃类溶剂由环烷烃和/或石蜡烃组成，沸点不低于 200ºC。 本发明使用该烃类溶剂制备的印刷油墨具有良好的乳化性、雾化性、定型性和干燥性。
• Adhesive composition, adhesive sheet, and method for producing same
  申请人：TOYO INK SC HOLDINGS CO., LTD.

  公开号：US11130890B2

  公开（公告）日：2021-09-28

  An adhesive composition that exhibits excellent adhesive performance such as curved surface adhesiveness to low-polarity adherends and constant load peeling properties in high-temperature environments, and also an adhesive sheet and a method for producing the same.

  一种粘合剂组合物，具有优异的粘合性能，如与低极性被粘物的曲面粘合性和高温环境下的恒定负载剥离性，以及一种粘合片材和生产方法。
• Molecular Modulation of Surfactant Aggregation in Water: Effect of the Incorporation of Multiple Headgroups on Micellar Properties
  作者：Jayanta Haldar、Vinod K. Aswal、Prem S. Goyal、Santanu Bhattacharya

  DOI：10.1002/1521-3773(20010401)40:7<1228::aid-anie1228>3.0.co;2-i

  日期：2001.4.1
• Cosmetic composition
  申请人：KAO CORPORATION

  公开号：EP0411202B1

  公开（公告）日：1993-12-15