(2S,3S)-4-methylpentane-2,3-diol | 1012886-97-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S)-4-methylpentane-2,3-diol
• CAS: 1012886-97-3
• 化学式: C₆H₁₄O₂
• 分子量: 118.176
• InChiKey: RNKURRDNOYXATR-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  反-4-甲基-2-戊烯 生成 (±)-anti-4-methyl-2,3-pentanediol 、 (2S,3S)-4-methylpentane-2,3-diol
  参考文献：
  名称：

  氟化卟啉镊子：绝对构型 forerythroandthreoDiols、氨基醇和二胺的强大报告者

  摘要：

  报告了确定赤型和苏型二醇、氨基醇和二胺的绝对构型的通用且灵敏的非经验方案。通过增加金属卟啉的路易斯酸度，可以大大增强二醇与卟啉镊子系统的结合。在卟啉镊子主体和手性底物之间形成的超分子复合物表现出基于手性中心取代基的具有可预测符号的激子耦合双信号 CD 光谱。工作模型表明，观察到的卟啉镊子的螺旋度是通过与每个手性中心结合的卟啉环所经历的空间分化来决定的。研究了各种赤型和苏型底物以验证这种手性方法。他们的绝对配置是明确确定的，

  DOI：

  10.1021/ja0752639

文献信息

• TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
  申请人：Ando Shigeru

  公开号：US20140329829A1

  公开（公告）日：2014-11-06

  The disclosure relates to Compounds of Formula (I) and pharmaceutically acceptable derivatives thereof, where R 1 , R 4 , R 8 , R 9 , and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, pain associated with osteoarthritis, osteoarthritis, UI, an ulcer, IBD, and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof.

  本公开涉及化合物公式(I)及其药学上可接受的衍生物，其中R1，R4，R8，R9和m的定义如本文所述，包括含有化合物公式(I)或其药学上可接受的衍生物的有效量的组合物，以及用于治疗或预防疼痛、与骨关节炎相关的疼痛、骨关节炎、尿失禁、溃疡、炎症性肠病和肠易激综合征等疾病的方法，包括向需要治疗的动物中施用化合物公式(I)或其药学上可接受的衍生物的有效量。
• TREATMENT OF BURN PAIN BY TRPV1 MODULATORS
  申请人：SYLVESTRE George

  公开号：US20160213659A1

  公开（公告）日：2016-07-28

  The present invention is directed to a method for treating pain associated with a burn injury originating from a thermal exposure, from a radiation exposure, from contact with a chemical agent, and/or from friction in an animal, comprising administering to an animal in need thereof, an effective amount of the compound of formula (I), wherein Ar 1 , Ar 2 , X, R 3 and R 20 are as described herein.
• INDAZOLES AND USE THEREOF
  申请人：PURDUE PHARMA L.P.

  公开号：US20170001986A1

  公开（公告）日：2017-01-05

  In one aspect, the present disclosure provides indazoles of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R 3 , R 4 , R 5 , R 6 , Z 1 , Z 2 , Z 3 , and G are defined as set forth in the specification. Further, the present disclosure also provides compounds of Formulae II and IA, and the pharmaceutically acceptable salts and solvates thereof. The present disclosure is also directed to the use of compounds of Formulae I, II, and IA, and the pharmaceutically acceptable salts and solvates thereof, to treat a disorder responsive to the blockade of sodium channels. In one embodiment, compounds of the present disclosure are especially useful for treating pain.
• US9273043B2
  申请人：——

  公开号：US9273043B2

  公开（公告）日：2016-03-01
• US9630959B2
  申请人：——

  公开号：US9630959B2

  公开（公告）日：2017-04-25