2-(2,6-dimethylphenoxy)tetrahydro-2H-pyran | 117658-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2,6-dimethylphenoxy)tetrahydro-2H-pyran
• 英文别名: 2-(2,6-Dimethylphenoxy)oxane
• CAS: 117658-42-1
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: OLPOTNQVAKUNDI-UHFFFAOYSA-N

物化性质

• 沸点：
  303.0±42.0 °C(Predicted)
• 密度：
  1.033±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2,6-dimethylphenoxy)tetrahydro-2H-pyran 在 三氟化硼乙醚 、 sodium cyanoborohydride 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以92%的产率得到2,6-二甲基苯酚
  参考文献：
  名称：

  Simple and Regioselective Reductive Cleavage of Tetrahydropyranyl Ethers to Alcohols

  摘要：

  DOI：

  10.1021/jo00112a056
• 作为产物：
  描述：

  2,6-二甲基苯酚 、 3,4-二氢-2H-吡喃 在 sepiolite catalyst 作用下， 反应 0.25h， 以27%的产率得到2-(2,6-dimethylphenoxy)tetrahydro-2H-pyran
  参考文献：
  名称：

  Spanish Sepiolite Clay as a New Heterogeneous Catalyst for the Tetrahydropyranylation of Alcohols and Phenols

  摘要：

  OH-protection of alcohols and phenols by heating the hydroxylated compound with 3,4-dihydro-2H-pyrane in the presence of a readily available and inexpensive spanish sepiolite heterogeneous acid clay catalyst is described. Isolated yields, not optimized, were in the range 29-99%.

  DOI：

  10.1080/00397919408011737

文献信息

• Alpo₄and Alpo₄-Al₂O₃as New Heterogeneous Catalysts for the Solvent-Free Tetrahydropyranylation of Alcohols and Phenols
  作者：Juan M. Campelo、Angel Garcia、Fernando Lafont、Diego Luna、Jose M. Marinas

  DOI：10.1080/00397919208019088

  日期：1992.8

  OH-protection of alcohols and phenols by heating the hydroxylated compound with 3,4-dihydro-2H-pyrane in the presence of an AlPO4 or AlPO4-Al2O3 heterogeneous acid catalyst is described. Isolated yields, not optimized, were in the range 50-99%.
• Srikrishna A., Sattigeri J. A., Viswajanani R., Yelamaggad C. V., J. Org. Chem, 60 (1995) N 7, S 2260
  作者：Srikrishna A., Sattigeri J. A., Viswajanani R., Yelamaggad C. V.

  DOI：——

  日期：——
• PINHEY, JOHN T.;XUAN, PHAN THANH, AUSTRAL. J. CHEM., 41,(1988) N 1, 69-80
  作者：PINHEY, JOHN T.、XUAN, PHAN THANH

  DOI：——

  日期：——
• Simple and Regioselective Reductive Cleavage of Tetrahydropyranyl Ethers to Alcohols
  作者：A. Srikrishna、J. A. Sattigeri、R. Viswajanani、C. V. Yelamaggad

  DOI：10.1021/jo00112a056

  日期：1995.4
• Spanish Sepiolite Clay as a New Heterogeneous Catalyst for the Tetrahydropyranylation of Alcohols and Phenols
  作者：Juan M. Campelo、Angel Garcia、Fernando Lafont、Diego Luna、Jose M. Marinas

  DOI：10.1080/00397919408011737

  日期：1994.5

  OH-protection of alcohols and phenols by heating the hydroxylated compound with 3,4-dihydro-2H-pyrane in the presence of a readily available and inexpensive spanish sepiolite heterogeneous acid clay catalyst is described. Isolated yields, not optimized, were in the range 29-99%.