5,6-Dihydro-2,5,5-trimethyl-7(4H)-benzothiazolone | 109300-05-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,6-Dihydro-2,5,5-trimethyl-7(4H)-benzothiazolone
• 英文别名: 2,5,5-trimethyl-4,6-dihydro-1,3-benzothiazol-7-one
• CAS: 109300-05-2
• 化学式: C₁₀H₁₃NOS
• 分子量: 195.28
• InChiKey: ORHYJWXSILMVFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5,5-trimethyl-4,6-dihydro-1,3-benzothiazol-7-one;hydrobromide 、 potassium carbonate 以58%的产率得到
  参考文献：
  名称：

  UDAPUDI, V. T.;MAHAJANSHETTI, C. S., INDIAN J. CHEM., 25,(1986) N 12, 1269-1272

  摘要：

  DOI：

文献信息

• HETEROARYL COMPOUNDS AS P2Y1 RECEPTOR INHIBITORS
  申请人：Sutton James C.

  公开号：US20100093689A1

  公开（公告）日：2010-04-15

  The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型杂环芳基化合物及其类似物，它们是选择性抑制人类P2Y1受体的药物。本发明还提供了各种该药物的制剂和调节P2Y1受体活性治疗疾病的方法。
• BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：Rice Kenneth D.

  公开号：US20140073628A1

  公开（公告）日：2014-03-13

  The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula I and pharmaceutically acceptable salts thereof, wherein the variables are as defined herein.

  本发明涉及mTOR的抑制剂及其药学上可接受的盐或溶剂，以及使用它们的方法。抑制剂通常具有结构式I及其药学上可接受的盐，其中变量如本文所定义。
• Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
  申请人：EXELIXIS, INC.

  公开号：US20140107100A1

  公开（公告）日：2014-04-17

  The invention is directed 10 Compound's of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

  本发明涉及公式I的化合物，以及其药学上可接受的盐或溶剂化物，以及制备和使用这些化合物的方法。
• BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：Rice Kenneth

  公开号：US20140018347A1

  公开（公告）日：2014-01-16

  The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural Formula (I) wherein the variables are as defined herein.

  本发明涉及mTOR的抑制剂及其药学上可接受的盐或溶剂，以及使用它们的方法。抑制剂通常具有结构式（I），其中变量如本文所定义。
• UDAPUDI, V. T.;MAHAJANSHETTI, C. S., INDIAN J. CHEM., 25,(1986) N 12, 1269-1272
  作者：UDAPUDI, V. T.、MAHAJANSHETTI, C. S.

  DOI：——

  日期：——