1-(2-Methoxy-5-methylphenyl)-3-phenylprop-2-en-1-one | 876513-24-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2-Methoxy-5-methylphenyl)-3-phenylprop-2-en-1-one
• 英文别名: 1-(2-methoxy-5-methylphenyl)-3-phenylprop-2-en-1-one
• CAS: 876513-24-5
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: NEUQSOGPVIHBII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲苯甲醚 、 肉桂酰氯 在 zinc(II) oxide 作用下， 反应 0.17h， 以85%的产率得到1-(2-Methoxy-5-methylphenyl)-3-phenylprop-2-en-1-one
  参考文献：
  名称：

  Zinc oxide as a regioselective and heterogeneous catalyst for the synthesis of chalcones at room temperature

  摘要：

  Zinc oxide catalyzed synthesis of chalcones has been carried out under solvent-free conditions at room temperature. Activated as well as unactivated aromatics smoothly underwent Friedel-Crafts acylation with alpha,beta-unsaturated acid chlorides furnishing excellent yields of the corresponding chalcones. The zinc oxide can be recovered and reused at least three times without any appreciable loss in activity. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2012.06.012

文献信息

• Zinc oxide as a regioselective and heterogeneous catalyst for the synthesis of chalcones at room temperature
  作者：Parmeshwar E. More、Babasaheb P. Bandgar、Vinod T. Kamble

  DOI：10.1016/j.catcom.2012.06.012

  日期：2012.10

  Zinc oxide catalyzed synthesis of chalcones has been carried out under solvent-free conditions at room temperature. Activated as well as unactivated aromatics smoothly underwent Friedel-Crafts acylation with alpha,beta-unsaturated acid chlorides furnishing excellent yields of the corresponding chalcones. The zinc oxide can be recovered and reused at least three times without any appreciable loss in activity. (C) 2012 Elsevier B.V. All rights reserved.