2-氨基-乙磺酸烯丙基酰胺 | 1017367-73-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 2-氨基-乙磺酸烯丙基酰胺
• 英文名称: 2-Amino-ethanesulfonic acid allylamide
• 英文别名: 2-amino-N-prop-2-enylethanesulfonamide
• CAS: 1017367-73-5
• 化学式: C₅H₁₂N₂O₂S
• mdl: MFCD09883351
• 分子量: 164.228
• InChiKey: PQNHSCULQRTLSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基-乙磺酸烯丙基酰胺 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (2S,4S)-2-(2-Allylsulfamoyl-ethylcarbamoyl)-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester
  参考文献：
  名称：

  Synthesis and biological properties of new 1β-methylcarbapenems

  摘要：

  The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R-2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00270-4
• 作为产物：
  描述：

  2-(1,3-dioxoisoindol-2-yl)-N-prop-2-enylethanesulfonamide 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 2-氨基-乙磺酸烯丙基酰胺
  参考文献：
  名称：

  Synthesis and biological properties of new 1β-methylcarbapenems

  摘要：

  The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R-2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00270-4

文献信息

• Synthesis and biological properties of new 1β-methylcarbapenems
  作者：Kye Jung Shin、Kyung Ho Yoo、Dong Jin Kim、Sang Woo Park、Bong Suck Ko、Sang Joo Lee、Jae Doo Huh、Seung Yong Park

  DOI：10.1016/s0960-894x(98)00270-4

  日期：1998.7

  The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R-2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety. (C) 1998 Elsevier Science Ltd. All rights reserved.