2-氨基噻唑-5-磺酰胺 | 63735-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-氨基噻唑-5-磺酰胺
• 中文别名: 2-氨基-5-噻唑磺酰胺
• 英文名称: 2-amino-5-sulfamoylthiazole
• 英文别名: 2-amino-thiazole-5-sulfonic acid amide；2-Amino-thiazol-5-sulfonsaeure-amid；2-Aminothiazole-5-sulfonamide；2-amino-1,3-thiazole-5-sulfonamide
• CAS: 63735-95-5
• 化学式: C₃H₅N₃O₂S₂
• mdl: MFCD09907759
• 分子量: 179.224
• InChiKey: VGYHEIFRKKUZTD-UHFFFAOYSA-N

物化性质

• 密度：
  1.733

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  1-溴频哪酮 、 2-氨基噻唑-5-磺酰胺 以 乙醇 为溶剂， 反应 60.0h， 以10%的产率得到6-tert-butyl-imidazo[2,1-b]thiazole-2-sulfonic acid amide
  参考文献：
  名称：

  Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides

  摘要：

  A series of imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamide carbonic anhydrase inhibitors is described and their anticonvulsant activities are listed. Many of the compounds have the same degree of ionization as acetazolamide and methazolamide, but their higher lipophilicity means that they are more able to penetrate into the central nervous system. One compound, 6-tert-butyl-2-sulfamoylimidazo[2,1-b]-1,3,4-thiadiazole (8, UK-15,454) had an anticonvulsant ED50 of 2.6 mg/kg when administered orally to mice. 8 selectively increased cerebral blood flow in animals without producing a high level of metabolic acidosis.

  DOI：

  10.1021/jm00176a003
• 作为产物：
  描述：

  N-(5-sulfamoylthiazol-2-yl)acetamide 在 盐酸 作用下， 生成 2-氨基噻唑-5-磺酰胺
  参考文献：
  名称：

  Backer; Buisman, Recueil des Travaux Chimiques des Pays-Bas, 1944, vol. 63, p. 228

  摘要：

  DOI：

文献信息

• Pyrrazolo-pyrimidine derivatives
  申请人：Gatti McArthur Silvia

  公开号：US20060183756A1

  公开（公告）日：2006-08-17

  The present invention relates to pyrrazolo-pyrimidine derivatives of formula (I): wherein R 1 to R 4 and A are as defined in the specification, a process for the manufacture thereof, their use for treating or preventing metabotropic glutamate receptors mediated disorders, their use for the preparation of medicaments for treating such disorders and pharmaceutical compositions containing said derivatives.

  本发明涉及式(I)的吡唑并嘧啶衍生物：其中R1至R4和A如规范中所定义，其制造过程，它们用于治疗或预防代谢型谷氨酸受体介导的疾病，用于制备治疗此类疾病的药物和含有该衍生物的药物组合物。
• Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides
  作者：Ian T. Barnish、Peter E. Cross、Roger P. Dickinson、Brian Gadsby、Michael J. Parry、Michael J. Randall、Ian W. Sinclair

  DOI：10.1021/jm00176a003

  日期：1980.2

  A series of imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamide carbonic anhydrase inhibitors is described and their anticonvulsant activities are listed. Many of the compounds have the same degree of ionization as acetazolamide and methazolamide, but their higher lipophilicity means that they are more able to penetrate into the central nervous system. One compound, 6-tert-butyl-2-sulfamoylimidazo[2,1-b]-1,3,4-thiadiazole (8, UK-15,454) had an anticonvulsant ED50 of 2.6 mg/kg when administered orally to mice. 8 selectively increased cerebral blood flow in animals without producing a high level of metabolic acidosis.
• Backer; Buisman, Recueil des Travaux Chimiques des Pays-Bas, 1944, vol. 63, p. 228
  作者：Backer、Buisman

  DOI：——

  日期：——