1,3-diphenyl-3-(o-methoxyphenylsulfanyl)-propan-1-one | 1334750-49-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-diphenyl-3-(o-methoxyphenylsulfanyl)-propan-1-one
• 英文别名: (3S)-3-(2-methoxyphenyl)sulfanyl-1,3-diphenylpropan-1-one
• CAS: 1334750-49-0
• 化学式: C₂₂H₂₀O₂S
• 分子量: 348.466
• InChiKey: HSHOTTHARQQKDO-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲氧基苯硫酚 、 反式-查耳酮 在 bovine serum albumin 作用下， 以 水 为溶剂， 反应 18.0h， 生成 1,3-diphenyl-3-(o-methoxyphenylsulfanyl)-propan-1-one 、 1,3-diphenyl-3-(o-methoxyphenylsulfanyl)-propan-1-one
  参考文献：
  名称：

  Stereoselective thio-Michael addition to chalcones in water catalyzed by bovine serum albumin

  摘要：

  A biomimetic, inexpensive, and simple method for the stereoselective thio-Michael addition of thiols to chalcones has been developed using bovine serum albumin (BSA) as a catalyst. Optically active products are obtained in high yield and with enantiomeric excesses of up to 70%. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.06.024

文献信息

• Stereoselective thio-Michael addition to chalcones in water catalyzed by bovine serum albumin
  作者：Nicoletta Gaggero、Domenico Carlo Maria Albanese、Giuseppe Celentano、Stefano Banfi、Alice Aresi

  DOI：10.1016/j.tetasy.2011.06.024

  日期：2011.6

  A biomimetic, inexpensive, and simple method for the stereoselective thio-Michael addition of thiols to chalcones has been developed using bovine serum albumin (BSA) as a catalyst. Optically active products are obtained in high yield and with enantiomeric excesses of up to 70%. (C) 2011 Elsevier Ltd. All rights reserved.