2-(2-methoxyphenylthio)acetohydrazide | 1275744-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-methoxyphenylthio)acetohydrazide
• 英文别名: 2-[(2-Methoxyphenyl)sulfanyl]acetohydrazide；2-(2-methoxyphenyl)sulfanylacetohydrazide
• CAS: 1275744-80-3
• 化学式: C₉H₁₂N₂O₂S
• mdl: MFCD18373529
• 分子量: 212.272
• InChiKey: SQBJZXMIULOBEK-UHFFFAOYSA-N

物化性质

• 沸点：
  414.0±30.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-methoxyphenylthio)acetohydrazide 、 3,4,5-三甲氧基苯甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 2-(2-methoxyphenyl)sulfanyl-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]acetamide
  参考文献：
  名称：

  N-Acylhydrazones as inhibitors of PDE10A

  摘要：

  Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.100
• 作为产物：
  描述：

  2-甲氧基苯硫酚 在 potassium carbonate 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(2-methoxyphenylthio)acetohydrazide
  参考文献：
  名称：

  N-Acylhydrazones as inhibitors of PDE10A

  摘要：

  Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.100

文献信息

• ANTIBACTERIAL INHIBITORS
  申请人：McMaster University

  公开号：EP2882430A1

  公开（公告）日：2015-06-17
• US3972905A
  申请人：——

  公开号：US3972905A

  公开（公告）日：1976-08-03
• [EN] ANTIBACTERIAL INHIBITORS<br/>[FR] INHIBITEURS ANTIBACTÉRIENS
  申请人：UNIV MCMASTER

  公开号：WO2014022923A1

  公开（公告）日：2014-02-13

  Anti-bacterial compounds have been identified having the general structures defined by Formula (I), Formula (II), and Formula (III).
• N-Acylhydrazones as inhibitors of PDE10A
  作者：Jennifer L. Gage、Rene Onrust、Derek Johnston、Andrew Osnowski、Wendy MacDonald、Lee Mitchell、László Ürögdi、Alex Rohde、Kevin Harbol、Sasha Gragerov、György Dormán、Tom Wheeler、Vince Florio、Neil S. Cutshall

  DOI：10.1016/j.bmcl.2011.05.100

  日期：2011.7

  Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease. (C) 2011 Elsevier Ltd. All rights reserved.