N-ethyl-6-methylindoline | 86924-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-ethyl-6-methylindoline
• 英文别名: 1-Ethyl-6-methyl-2,3-dihydroindole
• CAS: 86924-98-3
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: UBYUTPWGFODSHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethyl-6-methylindoline 、 N,N-二甲基甲酰胺 、 三氯氧磷 生成 1-Ethyl-6-methyl-2,3-dihydroindole-5-carbaldehyde
  参考文献：
  名称：

  FLORVALL L.; KUMAR YATENDRA; ASK A. -L.; FAGERVALL I.; RENYI L.; ROSS S. +, J. MED. CHEM., 29,(1986) N 8, 1406-1412

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基吲哚 以50%的产率得到
  参考文献：
  名称：

  KUMAR, YATENDRA;FLORVALL, L., SYNTH. COMMUN., 1983, 13, N 6, 489-493

  摘要：

  DOI：

文献信息

• Kumar, Yatendra; Florvall, Lennart, Synthetic Communications, 1983, vol. 13, # 6, p. 489 - 494
  作者：Kumar, Yatendra、Florvall, Lennart

  DOI：——

  日期：——
• FLORVALL L.; KUMAR YATENDRA; ASK A. -L.; FAGERVALL I.; RENYI L.; ROSS S. +, J. MED. CHEM., 29,(1986) N 8, 1406-1412
  作者：FLORVALL L.、 KUMAR YATENDRA、 ASK A. -L.、 FAGERVALL I.、 RENYI L.、 ROSS S. +

  DOI：——

  日期：——
• NOVEL IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
  申请人：Tachibana Kazutaka

  公开号：US20110306615A1

  公开（公告）日：2011-12-15

  According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, —ORa or a C 1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C 1-6 alkyl group; m is selected from integers from 0 to 3; R 2 and R 3 are independently selected from a C 1-6 alkyl group; X 1 and X 2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E 1 ; E 1 is independently selected from a hydroxyl group, a halogen atom, a C 1-4 alkyl group, a cyano group, a C 1-4 alkoky group, a carbamoyl group, a C 1-4 alkylcarbamoyl group, a di(C 1-4 alkyl)carbamoyl group, an amino group, a C 1-4 alkylamino group, a di(C 1-4 alkylamino group, a sulfamoyl group, a C 1-4 alkylsulfamoyl group and a di(C 1-4 alkyl)sulfamoyl group; Z is —CON(—Ra)—, —CO—, —COO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO 2 —, —SO 2 N(—Ra)—, —SO 2 NR 1 —, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR 1 )CO—, —N(—Ra)SO 2 —, —N(SO 2 R 1 )SO 2 —, —N(—Ra)— or —N(—Ra)SO 2 N(—Rb)—; R 1 is independently a hydrogen atom, a hydroxyl group, a C 1-6 alkyl group which may be substituted by one or more substituents, a heterocyclic group which may be substituted by one or more substituents, an aryl group which may be substituted by one or more substituents, a C 3-8 cycloalkyl group which may be substituted by one or more substituents or a C 3-8 cycloalkenyl group which may be substituted by one or more substituents, or a salt, prodrug or solvate thereof is provided. Furthermore, a pharmaceutical composition containing the compound, and the like are also provided.
• US8470829B2
  申请人：——

  公开号：US8470829B2

  公开（公告）日：2013-06-25
• KUMAR, YATENDRA;FLORVALL, L., SYNTH. COMMUN., 1983, 13, N 6, 489-493
  作者：KUMAR, YATENDRA、FLORVALL, L.

  DOI：——

  日期：——