11-(4-methylphenyl)undecanoic acid | 108240-91-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-(4-methylphenyl)undecanoic acid
• 英文别名: 11-p-Tolyl-undecansaeure；11-p-tolyl-undecanoic acid
• CAS: 108240-91-1
• 化学式: C₁₈H₂₈O₂
• 分子量: 276.419
• InChiKey: FVUPZAXHDNJCDC-UHFFFAOYSA-N

物化性质

• 熔点：
  57.5-58.5 °C
• 沸点：
  235-238 °C(Press: 15 Torr)
• 密度：
  0.973 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  11-(4-methylphenyl)undecanoic acid 在 三乙胺 、 氯甲酸乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 11-(4-methylphenyl)undecanoyl 11-(4-methylphenyl)undecanoate
  参考文献：
  名称：

  具有带有芳族单元的脂肪酸链的新型磷脂酰胆碱脂质的合成。氧化稳定的流体磷脂膜的产生

  摘要：

  已经合成了二酰基磷脂类似物的第一实例，该二酰基磷脂类似物在其烃链的各个深度处包含芳族单元。由这些新合成脂质的超声处理的水悬浮液制得的膜具有氧化稳定性，并具有较长的保存期限。这些膜在环境温度下保持流体特性，使其成为膜蛋白重构研究的理想选择。

  DOI：

  10.1016/s0040-4039(02)00758-x
• 作为产物：
  描述：

  11-p-tolyl-undecanoic acid ethyl ester 在 氢氧化钾 、 oxonium 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以95%的产率得到11-(4-methylphenyl)undecanoic acid
  参考文献：
  名称：

  具有带有芳族单元的脂肪酸链的新型磷脂酰胆碱脂质的合成。氧化稳定的流体磷脂膜的产生

  摘要：

  已经合成了二酰基磷脂类似物的第一实例，该二酰基磷脂类似物在其烃链的各个深度处包含芳族单元。由这些新合成脂质的超声处理的水悬浮液制得的膜具有氧化稳定性，并具有较长的保存期限。这些膜在环境温度下保持流体特性，使其成为膜蛋白重构研究的理想选择。

  DOI：

  10.1016/s0040-4039(02)00758-x

文献信息

• Synthesis of surface-active substances from ?-chloro carboxylic acids
  作者：S. A. Dmitriev、N. M. Karavaev、A. V. Smirnova

  DOI：10.1007/bf00911439

  日期：1961.10
• Huisgen; Vossius, Monatshefte fur Chemie, 1957, vol. 88, p. 517,527
  作者：Huisgen、Vossius

  DOI：——

  日期：——
• Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion
  作者：F. Nappo、M. Loreto、G. Giugliano、E. Grella、K. Esposito、B. Lettieri、D. Giugliano

  DOI：10.1007/bf03345073

  日期：2002.7

  Fat emulsion infusion is routinely used as a source of calories and essential fatty acids for critically ill patients who may be at risk for acquired ventricular repolarization alterations due either to drugs or electrolyte disturbances. The aim of this study was to evaluate whether acute elevations of plasma free fatty acid concentrations influence the corrected Q-T interval (Q-Tc), Q-Tc dispersion and sympathetic nervous system activity in patients requiring parenteral nutrition. Thirty hospitalized patients (mean+/-SD: 62 +/- 17 yr of age) requiring total parenteral nutrition received an infusion of 10% (500 ml) triacylglycerol emulsion as a source of calories (450 Kcal); on another occasion, and in random order, the same patients received an infusion of 20% (500 ml) triacylglycerol emulsion (900 Kcal). The infusion lasted 8 h and was preceded by a sc injection of heparin (5000 U). Infusions of both 10% and 20% triacylglycerol emulsion increased plasma free fatty acid (p<0.001) and triacylglycerol (p<0.01) concentrations, and was associated with no significant change in mean BP, heart rate, and plasma catecholamines. At baseline, Q-Tc and Q-Tc dispersion were within the normal range (<440 milliseconds for QTc and <40 ms for QTc-d) and did not show any significant change at any time during infusion of triacylglycerol emulsion at both concentrations. In the setting of a balanced parenteral nutrition, acute elevation of plasma free fatty acid concentrations in critically ill patients do not modify ventricular repolarization. (C) 2002, Editrice Kurtis.
• US4356315A
  申请人：——

  公开号：US4356315A

  公开（公告）日：1982-10-26
• Synthesis of novel phosphatidylcholine lipids with fatty acid chains bearing aromatic units. Generation of oxidatively stable, fluid phospholipid membranes
  作者：Santanu Bhattacharya、Marappan Subramanian

  DOI：10.1016/s0040-4039(02)00758-x

  日期：2002.6

  The first examples of diacylphospholipid analogs, which contain aromatic units at various depths of their hydrocarbon chains, have been synthesized. The membranes produced from the sonicated aqueous suspensions of these newly synthesized lipids are oxidatively stable and possess long shelf life. These membranes maintain fluid character at ambient temperature making them ideal for membrane protein reconstitution

  已经合成了二酰基磷脂类似物的第一实例，该二酰基磷脂类似物在其烃链的各个深度处包含芳族单元。由这些新合成脂质的超声处理的水悬浮液制得的膜具有氧化稳定性，并具有较长的保存期限。这些膜在环境温度下保持流体特性，使其成为膜蛋白重构研究的理想选择。