(E)-1-(3-methoxyphenyl)-2-propyl-2-hexen-1-ol | 1610372-05-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-1-(3-methoxyphenyl)-2-propyl-2-hexen-1-ol
• 英文别名: (E)-1-(3-methoxyphenyl)-2-propylhex-2-en-1-ol
• CAS: 1610372-05-8
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: XOHHEGGTULMMAG-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-辛炔 、 间甲氧基苯甲醇 在 bis(1,5-cyclooctadiene)nickel (0) 、 1,3-双(2,6-二异丙基苯基)咪唑-2-烯 作用下， 以 苯 为溶剂， 反应 12.0h， 以73%的产率得到(E)-1-(3-methoxyphenyl)-2-propyl-2-hexen-1-ol
  参考文献：
  名称：

  Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes to Form Allylic Alcohols

  摘要：

  We have developed a redox-economical coupling reaction of alcohols and alkynes to form allylic alcohols under mild conditions. The reaction is redox-neutral as well as redox-economical and thus free from any additives such as a reductant or an oxidant. This atom-economical coupling can be applied for the conversion of both aliphatic and benzylic alcohols to the corresponding substituted allylic alcohols in a single synthetic operation.

  DOI：

  10.1021/ja500666h

文献信息

• Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes to Form Allylic Alcohols
  作者：Kenichiro Nakai、Yuji Yoshida、Takuya Kurahashi、Seijiro Matsubara

  DOI：10.1021/ja500666h

  日期：2014.6.4

  We have developed a redox-economical coupling reaction of alcohols and alkynes to form allylic alcohols under mild conditions. The reaction is redox-neutral as well as redox-economical and thus free from any additives such as a reductant or an oxidant. This atom-economical coupling can be applied for the conversion of both aliphatic and benzylic alcohols to the corresponding substituted allylic alcohols in a single synthetic operation.