2-氯-3-氟-5-甲基吡啶 | 34552-15-3

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氯-3-氟-5-甲基吡啶
• 英文名称: 2-chloro-3-fluoro-5-methylpyridine
• CAS: 34552-15-3
• 化学式: C₆H₅ClFN
• mdl: MFCD06658238
• 分子量: 145.564
• InChiKey: XZJURWKNRAGMCG-UHFFFAOYSA-N

物化性质

• 熔点：
  29-30 °C
• 沸点：
  92°C/25mmHg(lit.)
• 密度：
  1.264±0.06 g/cm3(Predicted)
• 溶解度：
  溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Chloro-3-fluoro-5-methylpyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Chloro-3-fluoro-5-methylpyridine
CAS number: 34552-15-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H5ClFN
Molecular weight: 145.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氯-3-氟-5-甲基吡啶 在 N-氯代丁二酰亚胺 、 偶氮二异丁腈 作用下， 以 氯苯 为溶剂， 反应 48.0h， 以53%的产率得到2-chloro-5-chloromethyl-3-fluoropyridine
  参考文献：
  名称：

  SUBSTITUTED ENAMINOCARBONYL COMPOUNDS

  摘要：

  本发明涉及新型取代烯胺羰基化合物，以及其制备方法和在控制动物害虫，特别是节肢动物，尤其是昆虫中的应用。

  公开号：

  US20090247551A1
• 作为产物：
  描述：

  2-fluoro-4-chloro-4-methyl-5,5-dimethoxypentanenitrile 在 盐酸 、 甲酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 1.08h， 生成 2-氯-3-氟-5-甲基吡啶
  参考文献：
  名称：

  Synthesis of halogenated pyridines via the copper(I) chloride-catalyzed addition of polyhaloacetonitriles to olefins

  摘要：

  DOI：

  10.1021/jo00225a027

文献信息

• [EN] COMPOUNDS USEFUL AS CSF1 MODULATORS<br/>[FR] COMPOSÉS UTILES EN TANT QUE MODULATEURS DU FACTEUR 1 DE STIMULATION DE COLONIES
  申请人：REDX PHARMA PLC

  公开号：WO2016051193A1

  公开（公告）日：2016-04-07

  This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

  这项发明涉及新颖化合物以及包含这些新颖化合物的药物组合物。更具体地，该发明涉及用作集落刺激因子1受体（cFMS）调节剂（例如cFMS抑制剂）的化合物。这项发明还涉及制备这些化合物的方法，这些化合物在治疗中的用途以及利用这些化合物进行治疗的方法。具体而言，该发明涉及利用这些化合物治疗癌症和自身免疫性疾病。
• [EN] BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION<br/>[FR] DÉRIVÉS BIS-(SULFONYLAMINO) DESTINÉS AU TRAITEMENT DE LA DOULEUR ET DE L'INFLAMMATION
  申请人：ASTRAZENECA AB

  公开号：WO2010132016A1

  公开（公告）日：2010-11-18

  The invention provides compounds of formula (I) wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.

  该发明提供了式（I）的化合物，其中R1、R2、R3、A和m如规范中定义，并且其光学异构体、消旋体和互变异构体，以及其药学上可接受的盐；以及它们的制备方法、含有它们的药物组合物以及它们在治疗中的应用。这些化合物是微粒体前列腺素E合成酶-1的抑制剂。
• [EN] SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES<br/>[FR] DÉRIVÉS DE SULFONYLPIPÉRAZINE QUI INTERAGISSENT AVEC LA PROTÉINE RÉGULATRICE DE LA GLUCOKINASE POUR LE TRAITEMENT DU DIABÈTE
  申请人：AMGEN INC

  公开号：WO2012027261A1

  公开（公告）日：2012-03-01

  The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

  本发明涉及与葡萄糖激酶调节蛋白相互作用的化合物I式，或其药用盐，此外，本发明涉及使用这些化合物或其药用盐治疗2型糖尿病和其他涉及葡萄糖激酶调节蛋白的疾病和/或症状的方法，以及含有这些化合物或其药用盐的药物组合物。
• 芳氧基苯胺基丙酸酯类化合物及其作为除草剂的应用
  申请人：长江大学

  公开号：CN105439945A

  公开（公告）日：2016-03-30

  芳氧基苯胺基丙酸酯类化合物，包括如下通式(I)表示的结构：其中，Ar为杂芳环或者稠杂环；杂芳环为稠杂环为R1、R2、R3、R4为H、卤素、硝基、甲氧基、甲基、甲酸甲酯基、氰基或三卤甲基中的一种或者几种；R5为H、C1～C4的直链或者支链的烷基，烷基上的氢被羟基、羧基、巯基、氨基、胍基、苯基取代；R6为甲基、乙基、丁基、中的一种；其优点是：此结构化合物，能保持芳氧苯氧丙酸酯类除草剂高效、速效、不易产生抗性等优点；同时可设计分子中的氨基酸官能团作为掺假氨基酸，抑制植物本身蛋白质的生物合成，对所有杂草具有防除作用。
• Base-Catalyzed Intramolecular Defluorination/O-Arylation Reaction for the Synthesis of 3-Fluoro-1,4-oxathiine 4,4-Dioxide
  作者：Jinlong Qian、Gaoxi Jiang、Lei Kang、Jinlong Zhang、Huameng Yang

  DOI：10.1055/a-1387-8862

  日期：2021.5

  A novel process involving base-catalyzed intramolecular defluorination/O-arylation of readily available α-fluoro-β-one-sulfones was realized and provided a series of 3-fluoro-1,4-oxathiine 4,4-dioxide derivatives in good to excellent yields. Unlike traditional defluorination reactions with stoichiometric base as the deacid reagent, this process is triggered by a catalytic amount of base (TMG: tetramethylguanidine)

  实现了一种新的方法，该方法涉及碱催化易得的α-氟代-β-砜的分子内脱氟/ O-芳基化反应，并提供了一系列3-氟-1,4-氧代草氨酸4,4-二氧化物衍生物。优异的产量。与传统的以化学计量的碱作为脱酸剂的脱氟反应不同，此过程是由催化量的碱（TMG：四甲基胍）触发的，分子筛既充当吸附剂以去除HF酸，又充当活化剂以帮助CF键断裂。