2-氯-3-氧代丁基乙酸酯 | 648432-76-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氯-3-氧代丁基乙酸酯
• 英文名称: 2-Chloro-3-oxobutyl acetate
• 英文别名: (2-chloro-3-oxobutyl) acetate
• CAS: 648432-76-2
• 化学式: C₆H₉ClO₃
• 分子量: 164.59
• InChiKey: WBOOXIGZTABOGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Thiazole-based Nitric Oxide donors having Acyl substuent(s) and uses thereof
  申请人：Assaf Peter

  公开号：US20080233163A1

  公开（公告）日：2008-09-25

  Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.

  本发明涉及新型NO供体化合物，其设计使得当NO从化合物中释放时，会形成一种天然代谢产物残留物，从而预防或减少重复给药时对化合物的耐受性发展。同时，本发明还涉及制备这种NO供体化合物的方法，包含这种化合物的制药组合物和医疗器械以及利用这种化合物治疗各种医学状况的方法。
• Nitric oxide donors and uses thereof
  申请人：Assaf Peter

  公开号：US20070021382A1

  公开（公告）日：2007-01-25

  Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.

  本发明涉及一种新型的NO供体化合物，其设计是当NO从化合物中释放时，会形成一种天然代谢物残留物，从而防止或减少反复给药时对该化合物的耐受性发展。此外，本发明还涉及制备这种NO供体化合物的方法，包含这种化合物的药物组合物和医疗器械，以及利用这些化合物治疗各种医疗状况的方法。
• US7189750B2
  申请人：——

  公开号：US7189750B2

  公开（公告）日：2007-03-13
• US7332513B2
  申请人：——

  公开号：US7332513B2

  公开（公告）日：2008-02-19
• US7368577B2
  申请人：——

  公开号：US7368577B2

  公开（公告）日：2008-05-06