N-[5-Chloro-6-(quinolin-3-yloxy)-pyridine-3-yl]-4-methoxy-benzenesulfonamide | 1013695-97-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[5-Chloro-6-(quinolin-3-yloxy)-pyridine-3-yl]-4-methoxy-benzenesulfonamide
• 英文别名: N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-methoxybenzenesulfonamide；N-(5-chloro-6-quinolin-3-yloxypyridin-3-yl)-4-methoxybenzenesulfonamide
• CAS: 1013695-97-0
• 化学式: C₂₁H₁₆ClN₃O₄S
• 分子量: 441.895
• InChiKey: BCMWMAIMINSPJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  98.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-羟基喹啉 、 5-硝基-2,3-二氯吡啶 生成 N-[5-Chloro-6-(quinolin-3-yloxy)-pyridine-3-yl]-4-methoxy-benzenesulfonamide
  参考文献：
  名称：

  METHOD FOR IDENTIFYING COMPOUNDS THAT ACT AS INSULIN-SENSITIZERS

  摘要：

  本发明涉及一种识别作为胰岛素敏感剂的化合物的方法。该方法可以包括在两种胰岛素敏感性测定中筛选试验化合物。该方法可以确定用于治疗由胰岛素抵抗引起的葡萄糖摄取紊乱的先导化合物。该发明还包括治疗胰岛素抵抗及相关疾病的方法。

  公开号：

  US20090318465A1

文献信息

• 3-AMINO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Deka Nabajyoti

  公开号：US20090247574A1

  公开（公告）日：2009-10-01

  The present invention provides novel compounds represented by the general formula (I): their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.

  本发明提供了一种由通式(I)所代表的新化合物：它们的药学上可接受的盐和药学上可接受的溶剂，用于治疗与胰岛素抵抗或高血糖有关的代谢紊乱。本发明还涉及制备通式(I)化合物和含有它们的制药组合物的过程。
• 3-amino-pyridine derivatives for the treatment of metabolic disorders
  申请人：Piramal Healthcare Limited

  公开号：US08269010B2

  公开（公告）日：2012-09-18

  The present invention provides novel compounds represented by the general formula (I): their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.

  本发明提供了一种新的化合物，其通式表示为（I）：其药学上可接受的盐和药学上可接受的溶剂，可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。本发明还涉及制备通式（I）化合物的方法和包含它们的药物组合物。
• Method for identifying compounds that act as insulin-sensitizers
  申请人：Piramal Life Sciences Limited

  公开号：EP2256496A2

  公开（公告）日：2010-12-01

  The present invention relates to a method for identifying compounds that act as insulin-sensitizers. The method can include screening of test compounds in two assays of insulin sensitivity. This method can identify lead compounds for the treatment of disorders caused by insulin resistance to glucose uptake. This invention also includes methods for treating insulin resistance and related disorders. The present invention further relates to compounds for use in the treatment of disorders caused by insulin resistance to glucose uptake and disorders related thereto.

  本发明涉及一种鉴定可作为胰岛素敏感剂的化合物的方法。该方法可包括在两种胰岛素敏感性试验中筛选试验化合物。该方法可鉴定出用于治疗由胰岛素对葡萄糖摄取的抵抗所引起的疾病的先导化合物。本发明还包括治疗胰岛素抵抗及相关疾病的方法。 本发明进一步涉及用于治疗由胰岛素对葡萄糖摄取的抵抗引起的紊乱和相关紊乱的化合物。
• 3 -AMINO- PYRIDINE DERIVATIVES FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Piramal Life Sciences Limited

  公开号：EP2094687A1

  公开（公告）日：2009-09-02
• US8269010B2
  申请人：——

  公开号：US8269010B2

  公开（公告）日：2012-09-18