1-<4-(Dimethylamino)phenyl>-3-<4-(trifluoromethyl)phenyl>-prop-2-en-1-one | 140885-43-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-<4-(Dimethylamino)phenyl>-3-<4-(trifluoromethyl)phenyl>-prop-2-en-1-one
• 英文别名: 1-[4-(Dimethylamino)phenyl]-3-[4-(trifluoromethyl)phenyl]-prop-2-en-1-one；(E)-1-[4-(dimethylamino)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
• CAS: 140885-43-4
• 化学式: C₁₈H₁₆F₃NO
• 分子量: 319.326
• InChiKey: MIYWJBLLHHXSFR-LFYBBSHMSA-N

物化性质

• 沸点：
  418.9±45.0 °C(Predicted)
• 密度：
  1.221±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-氨基巴豆腈 、 1-<4-(Dimethylamino)phenyl>-3-<4-(trifluoromethyl)phenyl>-prop-2-en-1-one 在 potassium tert-butylate 作用下， 以 乙腈 为溶剂， 以71%的产率得到3-Cyano-6-<4-(dimethylamino)phenyl>-2-methyl-4-<4-(trifluoromethyl)phenyl>pyridine
  参考文献：
  名称：

  Synthesis and characterization of fluorescent 4,6-disubstituted-3-cyano-2-methylpyridines

  摘要：

  4,6-Disubstituted-3-cyano-2-methylpyridines, easily prepared by treating alpha,beta-unsaturated carbonyl compounds with beta-aminocrotononitrile in the presence of potassium tert-butoxide, have been found to show intense fluorescence in the region of 400-552 nm. 3-Cyano-4,6-bis(4-methoxyphenyl)-and 3-cyano-4,6-di(2-furyl)-2-methylpyridines show more intense fluorescence than 7-diethylamino-4-methylcoumarin. The 3-cyano group of pyridines increases the fluorescence intensities and improves photostabilities.

  DOI：

  10.1039/p29920000201
• 作为产物：
  描述：

  对三氟甲基苯甲醛 、 二甲氨基苯乙酮 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以44%的产率得到1-<4-(Dimethylamino)phenyl>-3-<4-(trifluoromethyl)phenyl>-prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and characterization of fluorescent 4,6-disubstituted-3-cyano-2-methylpyridines

  摘要：

  4,6-Disubstituted-3-cyano-2-methylpyridines, easily prepared by treating alpha,beta-unsaturated carbonyl compounds with beta-aminocrotononitrile in the presence of potassium tert-butoxide, have been found to show intense fluorescence in the region of 400-552 nm. 3-Cyano-4,6-bis(4-methoxyphenyl)-and 3-cyano-4,6-di(2-furyl)-2-methylpyridines show more intense fluorescence than 7-diethylamino-4-methylcoumarin. The 3-cyano group of pyridines increases the fluorescence intensities and improves photostabilities.

  DOI：

  10.1039/p29920000201

文献信息

• Synthesis and characterization of fluorescent 4,6-disubstituted-3-cyano-2-methylpyridines
  作者：Masaki Matsui、Akira Oji、Koichi Hiramatsu、Katsuyoshi Shibata、Hiroshige Muramatsu

  DOI：10.1039/p29920000201

  日期：——

  4,6-Disubstituted-3-cyano-2-methylpyridines, easily prepared by treating alpha,beta-unsaturated carbonyl compounds with beta-aminocrotononitrile in the presence of potassium tert-butoxide, have been found to show intense fluorescence in the region of 400-552 nm. 3-Cyano-4,6-bis(4-methoxyphenyl)-and 3-cyano-4,6-di(2-furyl)-2-methylpyridines show more intense fluorescence than 7-diethylamino-4-methylcoumarin. The 3-cyano group of pyridines increases the fluorescence intensities and improves photostabilities.