1-[3-[[Diethoxy(oxido)phosphaniumyl]methyl]phenyl]ethanone | 339526-81-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3-[[Diethoxy(oxido)phosphaniumyl]methyl]phenyl]ethanone
• 英文别名: 1-[3-[[diethoxy(oxido)phosphaniumyl]methyl]phenyl]ethanone
• CAS: 339526-81-7
• 化学式: C₁₃H₁₉O₄P
• 分子量: 270.265
• InChiKey: PFMMNZPLWSIPSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[3-[[Diethoxy(oxido)phosphaniumyl]methyl]phenyl]ethanone 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 48.0h， 生成 m-Phosphonomethyl-alpha-methylphenylglycine
  参考文献：
  名称：

  Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

  摘要：

  The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00052-x
• 作为产物：
  描述：

  3'-甲基苯乙酮 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 生成 1-[3-[[Diethoxy(oxido)phosphaniumyl]methyl]phenyl]ethanone
  参考文献：
  名称：

  Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

  摘要：

  The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00052-x

文献信息

• Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors
  作者：Stuart J Conway、Jacqueline C Miller、Patrick A Howson、Barry P Clark、David E Jane

  DOI：10.1016/s0960-894x(01)00052-x

  日期：2001.3

  The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.