bis(2-pyridylmethyl)(8-hydroxy-quinoline-2-methyl)amine | 648896-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: bis(2-pyridylmethyl)(8-hydroxy-quinoline-2-methyl)amine
• 英文别名: 2-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol；2-({Bis[(pyridin-2-yl)methyl]amino}methyl)quinolin-8-ol；2-[[bis(pyridin-2-ylmethyl)amino]methyl]quinolin-8-ol
• CAS: 648896-31-5
• 化学式: C₂₂H₂₀N₄O
• 分子量: 356.427
• InChiKey: ACZGKJKOUXXCEU-UHFFFAOYSA-N

物化性质

• 沸点：
  522.8±45.0 °C(Predicted)
• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  bis(2-pyridylmethyl)(8-hydroxy-quinoline-2-methyl)amine 、 zinc(II) perchlorate 以 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Modulating Affinities of Di-2-picolylamine (DPA)-Substituted Quinoline Sensors for Zinc Ions by Varying Pendant Ligands

  摘要：

  We have developed a series of di-2-picolylamine (DPA)-substituted quinoline sensors, HQ1-4, bearing a pendant ligand at the 8 position of quinoline. UV-vis spectra of HQ1-4 showed similar variations to that of HQ5 but with different varying extents upon the titration of zinc ions. Fluorescence intensities of HQ1, HQ3, and HQ4 were enhanced 4-6 times upon the addition of 1 equiv of zinc ions under an aqueous buffer. Somewhat unexpectedly, HQ2 is nonfluorescent in the presence of metal ions, including zinc ions. The affinities of HQ sensors are distributed in a broad range from nanomolarity to femtomolarity by varying the pendant ligands near the coordination unit. More importantly, these new sensors exhibited very high selectivity for Zn2+ over Na+, K+, Mg2+, and Ca2+ at the millimolar level and over other transition metal ions at the micromolar level, except for Cd2+. These findings indicated that the incorporations of the pendant groups exerted no effect on the spectroscopic properties and selectivity of the parent fluorescent sensor, with the exception of HQ2. Finally, X-ray crystal structures of ZnHQ's revealed that the auxiliary pendant groups at the 8 position participated in zinc coordination and were able to tune the affinities of HQ sensors.

  DOI：

  10.1021/ic702393z
• 作为产物：
  描述：

  8-羟基喹哪啶 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 bis(2-pyridylmethyl)(8-hydroxy-quinoline-2-methyl)amine
  参考文献：
  名称：

  8-羟基喹啉-二（2-吡啶甲基）胺的钴，镍和铁配合物，用于光驱动氢的逸出†

  摘要：

  合成了基于五齿的8-羟基喹啉-二（2-吡啶甲基）胺配体的新型钴，镍和铁配合物，并对其进行了全面表征。还获得了钴和铁配合物的X射线结构，显示出通过与另外的第六配位体配位而采用伪八面体几何形状的趋势。然后研究了这些金属配合物在电化学和光驱动条件下作为潜在的析氢催化剂（HEC）。特别是，测试了两种不同的光化学体系，涉及Ru（bpy）3 2+ /抗坏血酸或Ir（ppy）2（bpy）+/ TEA敏化剂/牺牲供体夫妇。电化学结果表明，这些金属络合物可作为有效的HEC。但是，在光化学条件下，只有钴化合物在基于钌和铱的体系中均表现出显着的析氢活性。另一方面，镍和铁配合物仅在铱基光化学体系中显示出相当大的光催化活性，而在钌基光化学体系中显示出可忽略的氢释放能力。

  DOI：

  10.1039/c7dt02666h

文献信息

• [EN] 8-HYDROXY QUINOLINE DERIVATIVES<br/>[FR] DERIVES DE QUINOLINE 8-HYDROXY
  申请人：PRANA BIOTECHNOLOGY LTD

  公开号：WO2004007461A1

  公开（公告）日：2004-01-22

  The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.

  本发明涉及一种用于治疗、改善和/或预防神经系统疾病，特别是神经退行性疾病的方法，包括向需要的受试者施用化合物(I)的有效量。本发明还涉及一种化合物(II)及其制备方法。
• 8-HYDROXY QUINOLINE DERIVATIVES
  申请人：PRANA BIOTECHNOLOGY LIMITED

  公开号：US20150094334A1

  公开（公告）日：2015-04-02

  The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.

  本发明描述了一种治疗受试者神经疾病的方法，包括向需要治疗的受试者施用公式中的化合物或其药学上可接受的盐、水合物或溶剂化物的治疗有效量。
• 8-Hydroxy quinoline derivatives
  申请人：Barnham Kevin Jeffrey

  公开号：US20080161353A1

  公开（公告）日：2008-07-03

  The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.

  本发明描述了一种治疗主体神经系统疾病的方法，该方法包括向需要治疗的主体中给予一定治疗效果的化合物，该化合物的化学式如下，或其药学上可接受的盐、水合物或溶剂化物。
• METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME
  申请人：Bush Ashley

  公开号：US20100069393A1

  公开（公告）日：2010-03-18

  The present invention relates generally to therapeutic agents, formulations comprising them and their use in the treatment, amelioration and/or prophylaxis of glioma brain tumours and related conditions. The therapeutic agent comprises two fused 6-membered rings with at least a nitrogen at position 1 and a hydroxyl at position 8.
• US7619091B2
  申请人：——

  公开号：US7619091B2

  公开（公告）日：2009-11-17