(S)-1-2H-octyl 4-methylbenzenesulfonate | 146801-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-2H-octyl 4-methylbenzenesulfonate
• 英文别名: (1S)-1-(p-tolylsulfonyloxy)-[1-(2)H1]-octane；[(1S)-1-deuteriooctyl] 4-methylbenzenesulfonate
• CAS: 146801-59-4
• 化学式: C₁₅H₂₄O₃S
• 分子量: 285.412
• InChiKey: LYQJBZLAANNIER-GFAIVKHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-1-2H-octyl 4-methylbenzenesulfonate 在 lithium aluminium tetrahydride 、 叠氮化锂 、 12-冠醚-4 、 水 、 sodium nitrite 作用下， 以 乙二醇二甲醚 、 乙醚 为溶剂， 反应 45.0h， 生成 (S)-<1-²H>-1-octanol
  参考文献：
  名称：

  Micellar effects in the nitrous acid deamination reaction of (R)-[1-2H]-1-octanamine

  摘要：

  The nitrous acid deamination of 1-octanamine (1) afforded mixtures of isomeric octenes, octanols, and octyl nitrites. The aggregation of 1.HClO4 in micelles induced the formation of dioctyl ethers and of 1-nitrooctane as additional products. In homogeneous solution (submicellar aqueous conditions or HOAc), [1-H-2]-1-octanol was obtained from [1-H-2]-1 with ca. 95% inversion of configuration. Above the critical micelle concentration, the enantiomeric purity of [1-H-2]-1-octanol decreased while [1-H-2]-1-nitrooctane was formed with ca.90% retention of configuration. 1-Octyl..NO2 radical pairs, rather than ion pairs, are likely to intervene on the retentive route to 1-nitrooctane and 1-octyl nitrite. Equilibration, via NO exchange, of (R)-[1-H-2]-1-octyl nitrite with the more abundant (S)-[1-H-2]-1-octanol is thought to account for the diminished ee of both products.

  DOI：

  10.1021/jo00057a025
• 作为产物：
  描述：

  辛酸乙酯 在 吡啶 、 lithium aluminium deuteride 、 草酰氯 、 B-isopinocampheyl-9-borabicyclo[3.3.1]nonane 、 二甲基亚砜 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 65.0h， 生成 (S)-1-2H-octyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  共轭脂肪酸生物合成中机制多样性的拓扑研究

  摘要：

  氧化主题的变化：FAD2型去饱和酶在柔性脂质底物上进行CH活化反应的精度令人惊讶。已经使用氘标记的底物探索了这些酶活性位点中可用的构象空间，并且已经发现了新的半蚀构象异构体的证据。该方案显示了一些原型底物构象。

  DOI：

  10.1002/anie.201202080

文献信息

• Enantioselective Synthesis of (<i>R</i>)- and (<i>S</i>)-1-²H-1-Octanol and Their Corresponding Amines
  作者：Diederik W. R. Balkenende、Seda Cantekin、Christopher J. Duxbury、Marcel H. P. van Genderen、E. W. Meijer、Anja R. A. Palmans

  DOI：10.1080/00397911.2010.527422

  日期：2012.2.15

  provided a one-step procedure from a commercially available starting compound to both enantiomers of 1-2H-1-octanol in good yields (>80%) and good enantiomeric excess (∼97%). The (S)-alcohols were converted to their corresponding (R)-amines, which showed ee's around 90%. GRAPHICAL ABSTRACT

  摘要 1-2H-1-辛醇的两种对映体都是在乙醇脱氢酶 (ADH)（ADH-T 或 ADH-LB）作为生物催化剂的情况下，通过酶促还原氘代辛醛获得的，具有良好的产率、纯度和对映体过量。 (>95%)。辅因子烟酰胺腺嘌呤二核苷酸磷酸通过添加异丙醇再生。为了简化合成路线，使用相同的酶和相同的辅因子但添加氘代异丙醇对辛醛的直接还原进行了评估。这提供了从市售起始化合物到 1-2H-1-辛醇的两种对映异构体的一步程序，产率良好 (>80%) 和对映体过量 (~97%)。(S)-醇被转化为其相应的(R)-胺，其显示ee约为90%。图形概要
• Micellar effects in the nitrous acid deamination reaction of (R)-[1-2H]-1-octanamine
  作者：Daniel Brosch、Wolfgang Kirmse

  DOI：10.1021/jo00057a025

  日期：1993.2

  The nitrous acid deamination of 1-octanamine (1) afforded mixtures of isomeric octenes, octanols, and octyl nitrites. The aggregation of 1.HClO4 in micelles induced the formation of dioctyl ethers and of 1-nitrooctane as additional products. In homogeneous solution (submicellar aqueous conditions or HOAc), [1-H-2]-1-octanol was obtained from [1-H-2]-1 with ca. 95% inversion of configuration. Above the critical micelle concentration, the enantiomeric purity of [1-H-2]-1-octanol decreased while [1-H-2]-1-nitrooctane was formed with ca.90% retention of configuration. 1-Octyl..NO2 radical pairs, rather than ion pairs, are likely to intervene on the retentive route to 1-nitrooctane and 1-octyl nitrite. Equilibration, via NO exchange, of (R)-[1-H-2]-1-octyl nitrite with the more abundant (S)-[1-H-2]-1-octanol is thought to account for the diminished ee of both products.
• Topological Study of Mechanistic Diversity in Conjugated Fatty Acid Biosynthesis
  作者：Palash Bhar、Darwin W. Reed、Patrick S. Covello、Peter H. Buist

  DOI：10.1002/anie.201202080

  日期：2012.7.2

  Variations on an oxidative theme: The precision with which FAD2‐type desaturases carry out CH activation reactions on flexible lipidic substrates is astonishing. The conformational space available within the active site of these enzymes has been explored using deuterium‐labeled substrates, and evidence for a novel quasi‐eclipsed conformer has been uncovered. The scheme shows some prototypical substrate

  氧化主题的变化：FAD2型去饱和酶在柔性脂质底物上进行CH活化反应的精度令人惊讶。已经使用氘标记的底物探索了这些酶活性位点中可用的构象空间，并且已经发现了新的半蚀构象异构体的证据。该方案显示了一些原型底物构象。