2-氯-5-乙基噻唑 | 857549-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-氯-5-乙基噻唑
• 英文名称: 2-chloro-5-ethyl-1,3-thiazole
• 英文别名: 5-ethyl-2-chloro-thiazole；5-Aethyl-2-chlor-thiazol；2-Chloro-5-ethylthiazole
• CAS: 857549-84-9
• 化学式: C₅H₆ClNS
• mdl: MFCD11847551
• 分子量: 147.628
• InChiKey: PDCCSNAOZCFXCN-UHFFFAOYSA-N

物化性质

• 沸点：
  192-193 °C
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯-5-乙基噻唑 在 盐酸 、 溶剂黄146 作用下， 生成 4-(5-ethyl-thiazole-2-sulfonyl)-aniline
  参考文献：
  名称：

  Ganapathi; Venkataraman, Proceedings - Indian Academy of Sciences, Section A, 1948, # 28, p. 556,559

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 copper(II) sulfate 、 sodium chloride 作用下， 生成 2-氯-5-乙基噻唑
  参考文献：
  名称：

  Ganapathi; Venkataraman, Proceedings - Indian Academy of Sciences, Section A, 1945, # 22, p. 362,376

  摘要：

  DOI：

文献信息

• [EN] 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES<br/>[FR] BENZAMIDES À SUBSTITUTION 1,3-THIAZOL-2-YL
  申请人：EVOTEC AG

  公开号：WO2016091776A1

  公开（公告）日：2016-06-16

  The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式（I）所述和定义的1,3-噻唑-2-基取代苯甲酰胺化合物，以及包含所述化合物的药物组合物和药物组合物的用途，用于制造用于治疗或预防疾病的药物组合物，特别是神经源性疾病，作为唯一药剂或与其他活性成分组合使用。
• Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives
  作者：Limin Liu、Zhengjie Wang、Chao Gao、Honglin Dai、Xiaojie Si、Yang Zhang、Yaqi Meng、Jiaxin Zheng、Yu Ke、Hongmin Liu、Qiurong Zhang

  DOI：10.1016/j.bmcl.2021.128268

  日期：2021.11

  novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized, and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound 17v displayed potent anti-proliferative activity on H1975 (IC50 = 2.27 μΜ), which was better than the positive control 5-FU (IC50 = 9.37 μΜ). Further biological evaluation studies showed that compound

  为了寻找高效的抗肿瘤新药，设计合成了一系列新型三氟甲基取代的嘧啶衍生物，并通过MTT评估了对四种人类肿瘤细胞（PC-3、MGC-803、MCF-7和H1975）的生物活性。化验。化合物17v对H1975显示出有效的抗增殖活性（IC 50  = 2.27 μM），优于阳性对照5-FU（IC 50  = 9.37 μM）。进一步的生物学评价研究表明，化合物17v 可诱导H1975细胞凋亡，并将细胞周期阻滞在 G2/M 期。此外，化合物17v通过增加促凋亡蛋白 Bax 和 p53 的表达并下调抗凋亡蛋白 Bcl-2 诱导 H1975 细胞凋亡。此外，化合物17v能够紧密嵌入 EGFR 的活性口袋中。总之，这些结果表明化合物17v具有作为进一步研究的先导化合物的潜力。
• [EN] PYRAZOLE DERIVATIVES WHICH MODULATE STEAROYL-COA DESATURASE<br/>[FR] DÉRIVÉS DE PYRAZOLE QUI MODULENT LA STÉAROYL-COA DÉSATURASE
  申请人：NOVARTIS AG

  公开号：WO2011039358A1

  公开（公告）日：2011-04-07

  The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

  本发明提供了能够调节硬脂酰辅酶A脱饱和酶活性的杂环衍生物。还涵盖了利用这些衍生物调节硬脂酰辅酶A脱饱和酶活性的方法以及包含这些衍生物的药物组合物。
• ALKOXYIMINO DERIVATIVE AND PEST CONTROL AGENT
  申请人：Fukumoto Shunichirou

  公开号：US20130102568A1

  公开（公告）日：2013-04-25

  [PROBLEMS] The present invention provides a novel alkoxyimino derivative or a salt thereof, as well as to a pest control agent containing the derivative or salt thereof as an active ingredient, which shows an excellent pest control effect on a wide range of pests in the agricultural and horticultural field and is also capable of controlling resistant pests. [MEANS FOR SOLVING PROBLEMS] The novel alkoxyimino derivative is characterized by being represented by general formula [I] (in the formula, X, R 1 , R 2 and Q are as defined in the specification) and the post control agent is characterized by containing as an active ingredient the alkoxyimino derivative or a salt thereof.

  本发明提供了一种新颖的烷氧基亚胺衍生物或其盐，以及一种含有该衍生物或其盐作为活性成分的杀虫剂，该杀虫剂对农业和园艺领域中广泛范围的害虫具有出色的杀虫效果，并且还能够控制抗性害虫。该新颖的烷氧基亚胺衍生物的特征在于其由通式[I]表示（在该式中，X、R1、R2和Q的定义如规范中所述），杀虫剂的特征在于其含有烷氧基亚胺衍生物或其盐作为活性成分。
• [EN] MESOIONIC PESTICIDES<br/>[FR] PESTICIDES MÉSOIONIQUES
  申请人：DU PONT

  公开号：WO2009099929A1

  公开（公告）日：2009-08-13

  Disclosed are compounds of Formula 1, wherein X is O or S; Y is O or S; and R1, R2, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  揭示了Formula 1中的化合物，其中X为O或S；Y为O或S；R1、R2、R3和R4如披露所定义。还披露了含有Formula 1中化合物的组合物以及控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与本发明的化合物或组合物的生物有效量接触。