2,3-Dimethyl-4-phenylfuran | 5109-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Dimethyl-4-phenylfuran
• 英文别名: 2.3-Dimethyl-4-phenyl-furan
• CAS: 5109-66-0
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: KXTVPPDUMAKZGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2932190090

反应信息

• 作为产物：
  描述：

  1-溴-2-丁炔 、 2-溴苯乙酮 在 indium 、 sodium hydroxide 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 水 、 二甲基亚砜 为溶剂， 反应 4.0h， 以57%的产率得到2,3-Dimethyl-4-phenylfuran
  参考文献：
  名称：

  Indium-mediated allenylation of arylacyl bromides in a route for the synthesis of substituted furans

  摘要：

  A three-step, single purification procedure has been developed for the concise synthesis of substituted furans from arylacyl bromides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.06.107

文献信息

• Reaction of tributyltin enolates with α-halogeno ketones: a new route to furan derivatives
  作者：Masanori Kosugi、Izumi Takano、Isao Hoshino、Toshihiko Migita

  DOI：10.1039/c39830000989

  日期：——

  The reaction of tributyltin enolates with α-halogeno ketones gave substituted furans which were not derived from the normal cross-coupling products, 1,4-diketones, but were formed instead through addition of the tin enolate to the α-halogeno ketones.

  三丁基锡烯酸酯与α-卤代酮的反应产生了取代的呋喃，该呋喃不是由正常的交叉偶联产物1,4-二酮衍生而来的，而是通过将烯醇锡添加到α-卤代酮中而形成的。
• Direct β-Arylation of Furans with Aryl Iodides Catalyzed by Dinuclear Palladium Complexes
  作者：Naofumi Tsukada、Takahiro Goto、Hayate Kato

  DOI：10.3987/com-17-13824

  日期：——

  Dinuclear palladium complexes formed by a chelate-bridging ligand showed beta-selectivity in the direct arylation of furans with iodoarenes. In contrast, the arylation using PPh3, or bpy as ligands gave alpha-arylfurans as major products. The arylation can be applied to several furans bearing functional groups except electron-withdrawing groups.
• KOSUGI, MASANORI;TAKANO, IZUMI;HOSHINO, ISAO;MIGITA, TOSHIHIKO, J. CHEM. SOC. CHEM. COMMUN., 1983, N 18, 989-990
  作者：KOSUGI, MASANORI、TAKANO, IZUMI、HOSHINO, ISAO、MIGITA, TOSHIHIKO

  DOI：——

  日期：——
• Indium-mediated allenylation of arylacyl bromides in a route for the synthesis of substituted furans
  作者：Mei-Huey Lin、Chung-Kai Kuo、Yen-Chih Huang、Yu-Ting Tsai、Chang-Hsien Tsai、Kung-Yu Liang、Yi-Syuan Li、Tsung-Hsun Chuang

  DOI：10.1016/j.tet.2014.06.107

  日期：2014.9

  A three-step, single purification procedure has been developed for the concise synthesis of substituted furans from arylacyl bromides. (C) 2014 Elsevier Ltd. All rights reserved.