Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products
本文描述了由FeCl 3 ·6H 2 O /乙醛介导的对缩酮/缩醛的轻度和有效催化脱保护。铁(III)/醛系统的多功能性和高化学选择性通过大量实例证明。在硅胶垫上过滤,然后蒸发掉挥发性副产物后,几乎定量分离了脱保护的酮/醛。