tin tetrakis(indolyldithiocarbamate) | 1021704-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tin tetrakis(indolyldithiocarbamate)
• 英文别名: [Sn(indtc)4]；2,3-Dihydroindole-1-carbodithioate;tin(4+)
• CAS: 1021704-83-5
• 化学式: C₃₆H₃₂N₄S₈Sn
• 分子量: 895.915
• InChiKey: SRHZPBAHUNFFOZ-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  7.14
• 重原子数：
  49
• 可旋转键数：
  0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  145
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  sodium indolinedithiocarbamate 、 四氯化锡 以 甲醇 为溶剂， 以55%的产率得到tin tetrakis(indolyldithiocarbamate)
  参考文献：
  名称：

  Mononuclear indolyldithiocarbamates of SnCl4 and R2SnCl2: Spectroscopic, thermal characterizations and cytotoxicity assays in vitro

  摘要：

  Several mononuclear Sn compounds ranging from mono to tetrakisindoline dithiocarbamates have been synthesized and characterized. Various spectroscopic techniques in combination with microanalytical data lead to the formation of 1:2 and 1:4 (Sn:Naindtc) type complexes depending on the molar ratio of the sodium salt of indolinedithiocarbamate employed. A symmetrical bidentate coordination of the indolinedithiocarbamate has been observed in all the cases as evident by a single sharp band at 1000 cm(-1) in their IR spectra. The compounds were found to adopt an octahedral arrangement around the Sn atom as evident from their 119 Sn NMR data. The TGA/DSC pro. le of the ligand exhibits a two-stage thermogram while the complexes decompose in three steps leading to the formation of tin-sulfide as the eventual end product. The in vitro cytotoxicity of butyl and phenyl analogues has been studied against the standard human tumor cell lines. The compounds have also been screened for their antifungal and antibacterial activity against E. coli, S. aureus, C. albicans and A. flavus. The results indicated the compounds to be active. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2007.12.026

文献信息

• Mononuclear indolyldithiocarbamates of SnCl4 and R2SnCl2: Spectroscopic, thermal characterizations and cytotoxicity assays in vitro
  作者：Sadaf Khan、Shahab A.A. Nami、K.S. Siddiqi

  DOI：10.1016/j.jorganchem.2007.12.026

  日期：2008.3

  Several mononuclear Sn compounds ranging from mono to tetrakisindoline dithiocarbamates have been synthesized and characterized. Various spectroscopic techniques in combination with microanalytical data lead to the formation of 1:2 and 1:4 (Sn:Naindtc) type complexes depending on the molar ratio of the sodium salt of indolinedithiocarbamate employed. A symmetrical bidentate coordination of the indolinedithiocarbamate has been observed in all the cases as evident by a single sharp band at 1000 cm(-1) in their IR spectra. The compounds were found to adopt an octahedral arrangement around the Sn atom as evident from their 119 Sn NMR data. The TGA/DSC pro. le of the ligand exhibits a two-stage thermogram while the complexes decompose in three steps leading to the formation of tin-sulfide as the eventual end product. The in vitro cytotoxicity of butyl and phenyl analogues has been studied against the standard human tumor cell lines. The compounds have also been screened for their antifungal and antibacterial activity against E. coli, S. aureus, C. albicans and A. flavus. The results indicated the compounds to be active. (C) 2008 Elsevier B.V. All rights reserved.