N-acetyl-N-(2-hydroxy-phenyl)-glycine | 103205-54-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acetyl-N-(2-hydroxy-phenyl)-glycine
• 英文别名: N-Acetyl-N-(2-hydroxy-phenyl)-glycin；(N-Acetyl-2-oxy-anilino)-essigsaeure；2-(N-acetyl-2-hydroxyanilino)acetic acid
• CAS: 103205-54-5
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.202
• InChiKey: FHNRFYVXMIAYQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-acetyl-N-(2-hydroxy-phenyl)-glycine 、 乙酸酐 生成 4-乙酰基-3,4-二氢-苯并[1,4]恶嗪-2-酮
  参考文献：
  名称：

  Aminophenols. I. The Reaction of o-Aminophenol with Chloracetic Acid and Some Comments on the Formation of Phenmorpholones¹

  摘要：

  DOI：

  10.1021/jo01103a015
• 作为产物：
  描述：

  N-(2-hydroxy-phenyl)-glycine nitrile 在 sodium hydroxide 作用下， 生成 N-acetyl-N-(2-hydroxy-phenyl)-glycine
  参考文献：
  名称：

  Shimo, Bulletin of the Chemical Society of Japan, 1926, vol. 1, p. 228

  摘要：

  DOI：

文献信息

• Compositions comprising phenyl-glycine derivatives
  申请人：——

  公开号：US20030108496A1

  公开（公告）日：2003-06-12

  The invention relates to compositions and methods useful for treating a variety of cosmetic conditions and dermatological disorders, where the composition includes a phenyl glycine derivative represented by the following formula: 1 wherein, R 1 and R 2 are independently H, I, F, Cl, Br, OH, SH, NH 2 , NHNH 2 , alkyl, aralkyl, alkoxy, acetoxy, acyloxy group having 1 to 9 carbon atoms, and being attached at the 2, 3 or 4 position of the phenyl group, whereby when R 1 and/or R 2 are OH, SH, NH 2 , they may be acetylated or acylated with 1 to 9 carbon atoms; R 3 is H, formyl, acetyl, propanoyl, acyl, alkyl, aralkyl or an aryl group having 1 to 9 carbon atoms; R 4 is OH, NH 2 , NHOH, NHNH 2 , or OR; where R is an alkyl, aralkyl or aryl group having 1 to 9 carbon atoms; the H attached to any carbon or nitrogen atom may be substituted by I, F, Cl, Br, OH, SH, NH 2 , NHNH 2 , an alkyl, aralkyl, alkoxy or acyl group having 1 to 9 carbon atoms. Phenyl-glycine and its derivatives may be present as isomeric D or L, non-isomeric or racemic DL, as a free acid, salt, lactone, amide or ester form.

  本发明涉及用于治疗各种美容病症和皮肤病的组合物和方法，其中组合物包括由下式表示的苯基甘氨酸衍生物： 1 其中，R 1 和 R 2 独立地为 H、I、F、Cl、Br、OH、SH、NH 2 、NHNH 2 烷基、芳烷基、烷氧基、乙酰氧基、具有 1 至 9 个碳原子的酰氧基，且连接在苯基的 2、3 或 4 位，其中当 R 1 和/或 R 2 是 OH、SH、NH 2 它们可以是乙酰化的，也可以是带有 1 至 9 个碳原子的酰化的；R 3 是 H、甲酰基、乙酰基、丙酰基、酰基、烷基、芳基或具有 1 至 9 个碳原子的芳基；R 4 是 OH、NH 2 、NHOH、NHNH 2 或 OR；其中 R 是具有 1 至 9 个碳原子的烷基、芳基或芳基；与任何碳原子或氮原子相连的 H 可被 I、F、Cl、Br、OH、SH、NH 2 、NHNH 2 1 至 9 个碳原子的烷基、芳基、烷氧基或酰基取代。苯基甘氨酸及其衍生物可以 D 或 L、非同分异构体或外消旋 DL、游离酸、盐、内酯、酰胺或酯的形式存在。
• COMPOSITIONS COMPRISING PHENYL-GLYCINE DERIVATIVES
  申请人：Yu, Ruey J., Dr.

  公开号：EP1455734A1

  公开（公告）日：2004-09-15
• US6824786B2
  申请人：——

  公开号：US6824786B2

  公开（公告）日：2004-11-30
• [EN] COMPOSITIONS COMPRISING PHENYL-GLYCINE DERIVATIVES<br/>[FR] COMPOSITIONS COMPRENANT DES DERIVES DE PHENYLE-GLYCINE
  申请人：YU RUEY J

  公开号：WO2003045338A1

  公开（公告）日：2003-06-05

  The invention relates to compositions and methods useful for treating a variety of cosmetic conditions and dermatological disorders, where the composition includes a phenyl glycine derivative represented by the following formula&colon (I); wherein, R1 and R2 are independently H, I, F, Cl, Br, OH, SH, NH2, NHNH2 alkyl, aralkyl, alkoxy, acetoxy, acyloxy group having 1 to 9 carbon atoms, and being attached at the 2, 3 or 4 position of the phenyl group, whereby when R1 and/or R2 are OH, SH, NH2, they may be acetylated or acylated with 1 to 9 carbon atoms; R3 is H, formyl, acetyl, propanoyl, acyl, alkyl, aralkyl or an aryl group having 1 to 9 carbon atoms; R4 is OH, NH2 NHOH, NHNH2, or OR; where R is an alkyl, aralkyl or aryl group having 1 to 9 carbon atoms; the H attached to any carbon or nitrogen atom may be substituted by I, F, Cl, Br, OH, SH, NH2, NHNH2 an alkyl, alkoxy or acyl group having 1 to 9 carbon atoms. Phenyl-glycine and its derivatives may be present as isomeric D or L, non-isomeric or racemic DL, as a free acid, salt, lactone, amide or ester form.
• Aminophenols. I. The Reaction of o-Aminophenol with Chloracetic Acid and Some Comments on the Formation of Phenmorpholones¹
  作者：HAROLD H. FREEDMAN、ALBERT E. FROST

  DOI：10.1021/jo01103a015

  日期：1958.9