3'-(4-(2-benzylthiazol-4-yl)phenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione | 1262444-31-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3'-(4-(2-benzylthiazol-4-yl)phenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione
• 英文别名: 3-[4-(2-benzyl-1,3-thiazol-4-yl)phenyl]spiro[1,3-thiazolidine-2,3'-1H-indole]-2',4-dione
• CAS: 1262444-31-4
• 化学式: C₂₆H₁₉N₃O₂S₂
• 分子量: 469.588
• InChiKey: BDNMKXIGBIPXBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  靛红 、 巯基乙酸 、 4-(2-benzyl-thiazol-4-yl)-aniline 以 溶剂黄146 为溶剂， 以72%的产率得到3'-(4-(2-benzylthiazol-4-yl)phenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione
  参考文献：
  名称：

  Synthesis, characterization, and antimicrobial activity of 3′-(4-(2-substituted thiazol-4-yl)phenyl)spiro[indoline-3,2′-thiazolidine]-2,4′-diones

  摘要：

  Abstract magnified image A series of 3′‐(4‐(2‐methyl/phenyl/benzylthiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones was synthesized. The structures of the synthesized compounds were evaluated by analytical and spectral (IR, 1H NMR, 13C NMR, LC‐MS, and elemental analysis) methods. All the synthesized compounds were screened for qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the derivatives showed good activity towards Gram‐positive and Gram‐negative bacteria. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.503

文献信息

• Synthesis, characterization, and antimicrobial activity of 3′-(4-(2-substituted thiazol-4-yl)phenyl)spiro[indoline-3,2′-thiazolidine]-2,4′-diones
  作者：Pravin C. Mhaske、Shivaji H. Shelke、Rahul P. Jadhav、Hemant N. Raundal、Sachin V. Patil、Amar A. Patil、Vivek D. Bobade

  DOI：10.1002/jhet.503

  日期：2010.11

  Abstract magnified image A series of 3′‐(4‐(2‐methyl/phenyl/benzylthiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones was synthesized. The structures of the synthesized compounds were evaluated by analytical and spectral (IR, 1H NMR, 13C NMR, LC‐MS, and elemental analysis) methods. All the synthesized compounds were screened for qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the derivatives showed good activity towards Gram‐positive and Gram‐negative bacteria. J. Heterocyclic Chem., (2010).