4',4'''-biflavone | 1109-30-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4',4'''-biflavone
• 英文别名: 4,4'-bis-(4-oxo-4H-chromen-2-yl)-biphenyl；4',4'''-Biflavonyl；[4',4''']-Biflavone；2-[4-[4-(4-oxochromen-2-yl)phenyl]phenyl]chromen-4-one
• CAS: 1109-30-4
• 化学式: C₃₀H₁₈O₄
• 分子量: 442.471
• InChiKey: HTPYEYLGDZAIRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4'-Iodoflavone 在 铜 作用下， 生成 4',4'''-biflavone
  参考文献：
  名称：

  化学学会会议论文集。1959年8月

  摘要：

  DOI：

  10.1039/ps9590000201

文献信息

• Optimized Palladium(0)-catalyzed Suzuki Cross-coupling Reaction of Polystyrene-supported Selenenyl Flavanones: A Convenient Preparation of Biaryl-chromen-4-one
  作者：E Tang、Wen Li、Zhangyong Gao、Lianpeng Zhang、Qiushi Ma

  DOI：10.1002/cjoc.201280023

  日期：2012.3

  Application of the Suzuki cross‐coupling reaction for efficient synthesis of diverse substituted biaryl‐chromen‐4‐ones using an optimized palladium(0) catalyst system is reported. The coupling of arylboronic acids with the resin‐bound bromoflavanones which were prepared by organoselenium‐induced regioselective intramolecular cyclization of bromo‐2‐hydroxylchalcones proceeded smoothly. Biaryl‐chromen‐4‐ones

  据报道，使用优化的钯（0）催化剂体系，Suzuki交叉偶联反应在高效合成各种取代的联芳基-铬--4-酮中的应用。芳基硼酸与树脂键合的溴代黄酮的偶联反应顺利进行，该反应是通过有机硒诱导的溴代-2-羟甲基卤代烷的区域选择性分子内环化反应而进行的。联芳基-苯并吡喃-4-酮是由随后的氧化硒合成顺良好总产量在剔除。
• Synthesis of phospholipase A2 inhibitory biflavonoids
  作者：Jianjun Chen、Hyeun Wook Chang、Hyun Pyo Kim、Haeil Park

  DOI：10.1016/j.bmcl.2006.01.117

  日期：2006.5

  A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A(2) (PLA(2)). Among six classes of C-C biflavones designed, four classes of C-C biflavones, which have flavone-flavone subunit linkages at A ring-A ring, A ring-B ring, B ring-B ring, and B ring-C ring, were synthesized. The synthetic biflavones exhibited somewhat different inhibitory activities against sPLA(2)-IIA. Among them, the biflavone a having a C-C 4'-4' linkage showed comparable inhibitory activity with that of the natural biflavonoid, ochnaflavone, and 7-fold stronger activity than that of amentoflavone. Further chemical modification is being carried out in order to obtain the chemically optimized biflavonoids. (C) 2006 Elsevier Ltd. All rights reserved.
• Chen, 1967, vol. 5, p. A 14
  作者：Chen

  DOI：——

  日期：——