2-溴-1-(嘧啶-4-基)乙酮氢溴酸盐 | 845267-57-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-溴-1-(嘧啶-4-基)乙酮氢溴酸盐
• 英文名称: 2-bromo-1-pyrimidin-4-yl-ethanone Hydrobromide
• 英文别名: 2-bromo-1-pyrimidin-4-ylethanone;hydrobromide
• CAS: 845267-57-4
• 化学式: C6H6Br2N2O
• 分子量: 281.93
• InChiKey: MURXITKQFQHWJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.63
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  42.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DERIVES DE PYRIMIDYLPYRROLE POUVANT ETRE UTILISES COMME INHIBITEURS DE KINASES
  申请人：PHARMACIA & ITALIA S P A

  公开号：WO2005014572A1

  公开（公告）日：2005-02-17

  Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了公式（1）的吡啶基吡咯衍生物及其药用可接受的盐，如规范中定义的，其制备方法和包括它们的药物组合物；发明的化合物可能在治疗中对治疗与蛋白激酶活性失调相关的疾病，如癌症，具有用处。
• Pyrimidylpyrrole derivatives active as kinase inhibitors
  申请人：Vanotti Ermes

  公开号：US20050043323A1

  公开（公告）日：2005-02-24

  Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明公开了式（I）的吡啶基吡咯衍生物及其药学上可接受的盐，以及其制备方法和包含它们的制药组合物；本发明的化合物在治疗与蛋白激酶活性失调相关的疾病，如癌症方面可能有用。
• PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1660475A1

  公开（公告）日：2006-05-31
• US7279575B2
  申请人：——

  公开号：US7279575B2

  公开（公告）日：2007-10-09