甘氨酸-pNA | 21027-72-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甘氨酸-pNA
• 英文名称: Gly-Phe-paranitroanilide
• 英文别名: Gly-Phe-pNA；(2S)-2-[(2-aminoacetyl)amino]-N-(4-nitrophenyl)-3-phenylpropanamide
• CAS: 21027-72-5
• 化学式: C₁₇H₁₈N₄O₄
• 分子量: 342.354
• InChiKey: KNDZCZRECXTRHP-HNNXBMFYSA-N

物化性质

• 沸点：
  691.8±55.0 °C(Predicted)
• 密度：
  1.344±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  甘氨酸-pNA 在 氢溴酸 、 N,N'-二环己基碳二亚胺 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 (S)-2-{2-[2-(2-Amino-acetylamino)-acetylamino]-acetylamino}-N-(4-nitro-phenyl)-3-phenyl-propionamide; hydrobromide
  参考文献：
  名称：

  Kasafirek, Evzen; Bartik, Michal, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 2, p. 442 - 451

  摘要：

  DOI：

文献信息

• Identification of compounds that inhibit replication of human immunodeficiency virus
  申请人：Balzarini Maria Rene Jan

  公开号：US20050096319A1

  公开（公告）日：2005-05-05

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，该化合物类别可以抑制人类免疫缺陷病毒（HIV）的复制，并提供了识别这些化合物的方法。具体而言，发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺可以抑制HIV在人血清中的复制。实施例包括识别抑制HIV的修饰甘氨酰胺化合物的方法，分离和合成修饰甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
• Compounds That Inhibit Replication Of Human Immunodeficiency Virus
  申请人：Balzarini Maria Rene Jan

  公开号：US20080076824A1

  公开（公告）日：2008-03-27

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HUV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，该类化合物能够抑制人类免疫缺陷病毒（HIV）的复制，并提供了鉴定这些化合物的方法。具体来说，发现经酶法制备的α-羟基甘氨酰胺和人工合成的α-羟基甘氨酰胺能够抑制HIV在人血清中的复制。实施例包括鉴定抑制HUV的改性甘氨酰胺化合物的方法，分离和合成改性甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
• INDENTIFICATION OF COMPOUNDS THAT INHIBIT REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS
  申请人：Balzarini Jan Maria

  公开号：US20090170953A1

  公开（公告）日：2009-07-02

  The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.

  本发明涉及一种新型化合物类别的发现，这些化合物可以抑制人免疫缺陷病毒（HIV）的复制，并且还提供了识别这些化合物的方法。具体而言，发现了酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺可以在人血清中抑制HIV的复制。实施例包括识别抑制HIV的改性甘氨酰胺化合物的方法，分离和合成改性甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
• Determination of potassium ions in fluids
  申请人：THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA

  公开号：EP0286039A2

  公开（公告）日：1988-10-12

  The invention concerns a process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium substances that give rise to ammonium. The enzymes which are used may be for example a transferase, a hydrolase, an oxidoreductase or a lyase. An essential part of the invention is a method to exclude interferences by ions by masking the interfering ions with a bindig agent.

  本发明涉及一种测定流体中离子的方法和试剂，通过这种方法可以测量这些离子对酶活性的影响。例如，离子是钠、钾、钙、镁、锰、锂、铅、锌、铜、铁或其他重金属或非金属离子，包括氯化物、碳酸氢盐、质子、产生铵的铵物质。使用的酶可以是转移酶、水解酶、氧化还原酶或裂解酶等。本发明的一个重要部分是通过用结合剂掩盖干扰离子来排除离子干扰的方法。
• Determination of ions in fluids
  申请人：THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA

  公开号：EP0471391A2

  公开（公告）日：1992-02-19

  The invention concerns a process and a composition for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured and a binding agent is added for masking of interfering ions. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium substances that give rise to ammonium. The enyzmes which are used may be for example a transferase, a hydrolase, an oxidoreductase or a lyase.

  本发明涉及一种测定流体中离子的方法和组合物，其中测定了这些离子对酶活性的影响，并添加了一种结合剂以掩盖干扰离子。例如，这些离子是钠、钾、钙、镁、锰、锂、铅、锌、铜、铁或其他重金属或非金属离子，包括氯化物、碳酸氢盐、质子、产生铵的铵物质。所使用的酶可以是转移酶、水解酶、氧化还原酶或裂解酶等。