N,N-diethyl-2-acetylacetamid | 66480-89-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N-diethyl-2-acetylacetamid
• 英文别名: 2-acetyl-N,N-diethyl-3-oxobutanamide
• CAS: 66480-89-5
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: HYAHDFKEPJWISW-UHFFFAOYSA-N

物化性质

• 沸点：
  302.5±32.0 °C(Predicted)
• 密度：
  1.034±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  水 以27%的产率得到
  参考文献：
  名称：

  SAITO KIMITOSHI; SATO TADASHI, BULL. CHEM. SOC. JAP., 1979, 52, NO 12, 3601-3605,

  摘要：

  DOI：

文献信息

• Diversity in the Base-induced Photoreactions of Thiolane-2,4-dione and Derivatives. Reductive Ring Cleavage and Novel Rearrangements of the Carbon Skeleton
  作者：Kimitoshi Saito、Tadashi Sato

  DOI：10.1246/bcsj.52.3601

  日期：1979.12

  The irradiation of thiolane-2,4-dione (thiotetronic acid) and its derivatives, 1a–1d, in methanol in the presence of bases induced the reductive ring cleavage to give β,β′-diketo esters. The base-induced reductive ring cleavage was also observed in aprotic solvents, such as acetonitrile or acetone, although the products were obtained as β,β′-diketo amides in these cases. On the other hand, the irradiation

  在碱存在的情况下，在甲醇中对硫戊环-2,4-二酮（硫代特酮酸）及其衍生物 1a-1d 进行辐照诱导还原性环裂解，生成 β,β'-二酮酯。在非质子溶剂（如乙腈或丙酮）中也观察到碱诱导的还原环裂解，尽管在这些情况下获得的产物是 β,β'-二酮酰胺。另一方面，在碱存在的情况下，在水中照射 1a-1d 会引起碳骨架的重排，生成琥珀酸硫酐、γ-酮酰胺或琥珀酰胺以及还原产物。当吡啶用作水中光解的碱时，两种 3-乙酰基衍生物 1a 和 1b 产生 γ-酮硫醇和相应的二硫化物，这是由另一种类型的碳骨架重排产生的。
• Methods and compositions for performing analytical operations
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10030264B2

  公开（公告）日：2018-07-24

  Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.

  用于执行分析反应的方法和用于此类方法的组合物，这些方法的信号水平会因检测试剂对分析方法的其他成分（如其他试剂、固相成分、容器等）的非特异性吸附而降低。
• Methods and Compositions for Performing Analytical Operations
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20140017674A1

  公开（公告）日：2014-01-16

  Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.
• METHODS AND COMPOSITIONS FOR PERFORMING ANALYTICAL OPERATIONS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150125854A1

  公开（公告）日：2015-05-07

  Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.
• US8956816B2
  申请人：——

  公开号：US8956816B2

  公开（公告）日：2015-02-17