O-heptylhydroxylamine hydrochloride | 38945-25-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-heptylhydroxylamine hydrochloride
• 英文别名: O-heptylhydroxylamine;hydrochloride
• CAS: 38945-25-4
• 化学式: C₇H₁₇NO*ClH
• 分子量: 167.679
• InChiKey: USUFYLLREWGPDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-2-甲基丙酰溴 、 O-heptylhydroxylamine hydrochloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到
  参考文献：
  名称：

  通过六氟异丙醇中的氮原子转移利用硫杂/硒唑烷酮的多米诺骨架扩展：室温进入六元 S/Se、N-杂环

  摘要：

  在此，在环境温度下，在六氟异丙醇 (HFIP) 中借助 TMS-叠氮化物，开发了一种高度区域选择性的多米诺骨架扩展工艺，该工艺将 2-氨基噻唑烷酮转化为六元 S，N-杂环。C2 叔胺作为噻唑烷酮部分上的潜在反应基团的功能是这一发展的关键，它允许用叠氮化物进行接力取代，并在无金属/酸的条件下进行后续的扩环。该反应还强调了从 TMS-叠氮化物到最终产物的分子间氮原子转移过程，其中不存在任何中间体叠氮噻唑烷酮。该策略可扩展到Se,N-杂环的类似合成，此外，还进行了后期药物修饰和后续转化。

  DOI：

  10.1021/acs.joc.1c02621
• 作为产物：
  描述：

  O-heptylhydroxylamine 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 O-heptylhydroxylamine hydrochloride
  参考文献：
  名称：

  Synthesis and Fungicidal Activity of Macrolactams and Macrolactones with an Oxime Ether Side Chain

  摘要：

  Three series of novel macrolactams and macrolactones - 12-alkoxyimino-tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by H-1 NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by H-1 NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuhn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.

  DOI：

  10.1021/jf072733+

文献信息

• Access to 3,3′-disubstituted peroxyoxindole derivatives and α-peroxyamides <i>via</i> azaoxyallyl cation-guided addition of hydroperoxides
  作者：Tishyasoumya Bera、Bandana Singh、Manoranjan Jana、Jaideep Saha

  DOI：10.1039/d2cc02378d

  日期：——

  The design and development of an azaoxyallyl cation templated strategy for rapid access to novel peroxide derivatives such as 3,3′-disubstituted peroxyoxindoles and α-peroxyamides.

  设计和开发一种以氮杂环丙烯阳离子为模板的策略，以快速获得新型过氧化物衍生物，例如3,3'-二取代过氧化氧化吲哚和α-过氧化酰胺。
• Experimental and Theoretical Investigation of an Azaoxyallyl Cation‐Templated Intramolecular Aryl Amination Leading to Oxindole Derivatives
  作者：Tishyasoumya Bera、Bandana Singh、Vincent Gandon、Jaideep Saha

  DOI：10.1002/chem.202201208

  日期：2022.11.7

  A detailed investigation on the reactivity of α-arylated azaoxyallyl cation undergoing intramolecular nucleophilic aryl-amination under catalyst-free conditions is presented. Azaoxyallyl cation-guided ortho-activation of the adjacent aromatic ring is central to this process aided by HFIP. This reaction manifold offers broad access to oxindole derivatives.

  详细研究了在无催化剂条件下进行分子内亲核芳基胺化的 α-芳基化氮杂氧烯丙基阳离子的反应性。在 HFIP 的辅助下，氮杂氧烯丙基阳离子引导的相邻芳环的邻位活化是该过程的核心。这种反应歧管提供了对羟吲哚衍生物的广泛使用。
• 45. Amino-oxy-derivatives. Part II. Some derivatives of N-hydroxydiguanide
  作者：P. Mamalis、J. Green、D. Mchale

  DOI：10.1039/jr9600000229

  日期：——
• Arylhydroxamates
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0161939B1

  公开（公告）日：1993-07-21
• US4607053A
  申请人：——

  公开号：US4607053A

  公开（公告）日：1986-08-19