3-anilino-1-(3-nitro-phenyl)-propan-1-one | 93733-62-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-anilino-1-(3-nitro-phenyl)-propan-1-one
• 英文别名: 3-Anilino-1-(3-nitro-phenyl)-propan-1-on；ω-Anilino-3-nitro-propiophenon；β-Anilino-m-nitropropiophenon；3-Anilino-1-(3-nitrophenyl)-1-propanone；3-anilino-1-(3-nitrophenyl)propan-1-one
• CAS: 93733-62-1
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: HZWOIIAHZHTTNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间硝基苯甲酰氯 在 乙醇 、 三乙胺 、 silver(l) oxide 作用下， 生成 3-anilino-1-(3-nitro-phenyl)-propan-1-one
  参考文献：
  名称：

  CpG DNA enhances the immune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs

  摘要：

  CpG DNA is DNA sequence that has immune stimulatory effects. Several tines of Investigation over the past few years indicate that CpG DNA plays an important role in the induction of immune responses to DNA vaccines. In this study, CpG DNA-containing synthetic oligodeoxynucleotide (CpG-ODN) was cloned into the eukaryotic expression plasmid encoding a fusion protein containing beta- galactosidase from E. coli and immunogenic epitopes of foot-and-mouth disease virus (FMDV) type O, and the immune responses induced by the plasmid were assayed. The results showed that guinea pigs immunized with the recombinant plasmid containing CpG-ODN generated a higher level of FMDV-neutralizing antibody and a stronger T cell proliferative response and protection against viral challenge than those receiving the plasmid containing no CpG-ODN. Our study demonstrated that it is an effective route to enhance the efficacy of DNA vaccines by inserting exogenous CpG DNA into the plasmids, and the DNA vaccine developed here Is a promising candidate to prevent FMDV infection.

  DOI：

  10.1007/bf03183393

文献信息

• CpG DNA enhances the immune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs
  作者：Guangjin Li、Yingjie Li、Weiyao Yan、Quanxin Xu、Yongqing Wu、Yong Xie、Yongjin You、Zhaoxin Zheng

  DOI：10.1007/bf03183393

  日期：2001.8

  CpG DNA is DNA sequence that has immune stimulatory effects. Several tines of Investigation over the past few years indicate that CpG DNA plays an important role in the induction of immune responses to DNA vaccines. In this study, CpG DNA-containing synthetic oligodeoxynucleotide (CpG-ODN) was cloned into the eukaryotic expression plasmid encoding a fusion protein containing beta- galactosidase from E. coli and immunogenic epitopes of foot-and-mouth disease virus (FMDV) type O, and the immune responses induced by the plasmid were assayed. The results showed that guinea pigs immunized with the recombinant plasmid containing CpG-ODN generated a higher level of FMDV-neutralizing antibody and a stronger T cell proliferative response and protection against viral challenge than those receiving the plasmid containing no CpG-ODN. Our study demonstrated that it is an effective route to enhance the efficacy of DNA vaccines by inserting exogenous CpG DNA into the plasmids, and the DNA vaccine developed here Is a promising candidate to prevent FMDV infection.