1-(2-propenyloxy)indole | 134792-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(2-propenyloxy)indole
• 英文别名: 1-(allyloxy)-1H-indole；1-Prop-2-enoxyindole
• CAS: 134792-60-2
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: FXXFWPSHZTTZKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-羟基吲哚 、 1-(2-propenyloxy)indole 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 以14%的产率得到1-tosyloxyindole
  参考文献：
  名称：

  Kawasaki, Toshiya; Kodama, Atsushi; Nishida, Tokiko, Heterocycles, 1991, vol. 32, # 2, p. 221 - 227

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(allyloxy)indolin-2-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以86%的产率得到1-(2-propenyloxy)indole
  参考文献：
  名称：

  Metal- and Oxidant-Free Modular Approach To Access N-Alkoxy Oxindoles via Aryne Annulation

  摘要：

  An unprecedented metal- and oxidant-free (intermolecular) approach to access N-alkoxy oxindoles via [3 + 2] cycloadition of in situ generated electrophilic species viz. aryne and (putative) aza-oxyallyl cation is reported. This approach is amenable to both C3-unsubstituted as well as C3-substituted oxindoles. A one-pot manipulation further makes this reaction highly practical. The versatility of this approach was demonstrated through valuable synthetic transformations.

  DOI：

  10.1021/acs.orglett.8b01972

文献信息

• NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS
  申请人：Denis Jean-Noel Marie Leon

  公开号：US20100144726A1

  公开（公告）日：2010-06-10

  The invention relates to the use of at least one compound of the formula (I), in which R and R 3 are particularly a hydrogen atom, R 1 is particularly a hydrogen atom or a methyl, ethyl or isobutyl mi group, R 4 , R 5 , R 6 and R 7 are independently a hydrogen atony, an alkoxyl group with 1 to 7 carbon atoms or a halogen atom, R 2 is a hydrogen atom, an O − group or an OH group, B is an N-GP 1 or NR c , group, GP 1 being a Boc or Cbz group, and R c is a hydrogen atom or a methyl or t-butyl group, for preparing a drug for treating conditions associated with bacterial infections, in particular for treating bacterial diseases.

  该发明涉及使用至少一种具有以下式（I）的化合物，其中R和R3特别是氢原子，R1特别是氢原子或甲基、乙基或异丁基mi基团，R4、R5、R6和R7独立地是氢原子、具有1至7个碳原子的烷氧基团或卤原子，R2是氢原子、O−基团或OH基团，B是N-GP1或NRc基团，GP1是Boc或Cbz基团，Rc是氢原子或甲基或叔丁基基团，用于制备用于治疗与细菌感染相关的疾病症状的药物，特别是用于治疗细菌性疾病。
• The synthesis of pyrano[3,2-e]indoles and pryano[2,3-f]indoles as rotationally restricted phenolic analogs of the neurotransmitter serotonin
  作者：John E. Macor、Kevin Ryan、Michael E. Newman

  DOI：10.1016/s0040-4020(01)88200-4

  日期：1992.1

  The synthesis of two rotationally restricted phenolic analogs (1a and 1b) of the neurotransmitter serotonin have been accomplished. The syntheses of 8.9-dihydropyrano[3,2-e]indole (13a) and 7,8-dihydropyrano[2,3-f]indole (13b), which formed the template for these targets, are outlined. These novel fused-indoles represent rotationally restricted phenolic analogs of 5-hydroxyindole. The reaction sequence

  已经完成了神经递质5-羟色胺的两个受旋转限制的酚类类似物（1a和1b）的合成。概述了形成这些靶标模板的8.9-二氢吡喃并[3,2-e]吲哚（13a）和7,8-二氢吡喃并[2,3-f]吲哚（13b）的合成。这些新颖的熔融吲哚代表5-羟基吲哚的旋转受限的酚类似物。使用克莱森重排，烯烃羟基化和分子内Mitsunobu反应的反应序列形成稠合的二氢吡喃环。
• Tyrosine-and tryptophan-containing peptides as antioxidants
  申请人：——

  公开号：US20030054976A1

  公开（公告）日：2003-03-20

  The invention relates to the use of tryptophan-containing, in particular tryptophan- and tyrosine-containing, peptides as antioxidants. The compounds can be used for the therapy or prophylaxis of syndromes and disorders associated with unwanted oxidative processes in the extracellular space.

  本发明涉及含色氨酸，特别是含色氨酸和酪氨酸的肽作为抗氧化剂的用途。这些化合物可用于治疗或预防与细胞外空间不需要的氧化过程有关的综合症和疾病。
• NOUVEAUX DERIVES INDOLIQUES, LEURS PROCEDES DE PREPARATION ET LEURS UTILISATIONS NOTAMMENT EN TANT QU'ANTIBACTERIENS
  申请人：Université Joseph Fourier

  公开号：EP2121601B1

  公开（公告）日：2016-06-15
• US5420282A
  申请人：——

  公开号：US5420282A

  公开（公告）日：1995-05-30