2-[4'-(3'-fluoropropoxy)phenyl]imidazo[1,2-a]pyridine | 960588-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4'-(3'-fluoropropoxy)phenyl]imidazo[1,2-a]pyridine
• 英文别名: 2-[4'-(3''-Fluoropropoxy)phenyl]imidazo[1,2-a]pyridine；2-[4-(3-fluoropropoxy)phenyl]imidazo[1,2-a]pyridine
• CAS: 960588-21-0
• 化学式: C₁₆H₁₅FN₂O
• 分子量: 270.306
• InChiKey: BCQLNMVTXCZBFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴-3-氟丙烷 、 4-咪唑并[1,2-a]吡啶-2-基-苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.5h， 生成 2-[4'-(3'-fluoropropoxy)phenyl]imidazo[1,2-a]pyridine
  参考文献：
  名称：

  COMPOUND HAVING AFFINITY FOR AMYLOID

  摘要：

  公开号：

  EP2042501B1

文献信息

• Novel Compound Having Affinity For Amyloid
  申请人：Tanifuji Shigeyuki

  公开号：US20100092387A1

  公开（公告）日：2010-04-15

  A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): or a salt thereof, wherein R 1 is a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms; R 2 is a radioactive halogen substituent; and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimer's disease comprising a compound represented by the above formula or a salt thereof is also provided.

  提供了一种与淀粉样物质具有亲和力、从正常组织中清除速度足够快且毒性被抑制（例如突变毒性）的化合物，该化合物由以下式子（1）表示：或其盐，其中R1是从氢、羟基、羧基、硫酸基、氨基、硝基、氰基、具有一到四个碳原子的烷基取代基或具有一到四个碳原子的烷氧基取代基中选择的基团；R2是放射性卤素取代基；m是0到2的整数。还提供了一种低毒性的阿尔茨海默病诊断剂，其包括上述式子或其盐所表示的化合物。
• Compound having affinity for amyloid
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：US08277777B2

  公开（公告）日：2012-10-02

  A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): or a salt thereof, wherein R1 is a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms; R2 is a radioactive halogen substituent; and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimer's disease comprising a compound represented by the above formula or a salt thereof is also provided.

  提供了一种与淀粉样物质具有亲和力、从正常组织中清除速度足够快且毒性被抑制，其由以下式子（1）表示：或其盐，其中R1是从氢、羟基、羧基、硫酸基、氨基、硝基、氰基、1至4个碳原子的烷基取代基或1至4个碳原子的烷氧基取代基中选择的基团；R2是放射性卤素取代基；m是0至2的整数，还提供了一种低毒性的阿尔茨海默病诊断剂，其包括上述式子或其盐所表示的化合物。
• NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：EP2042501A1

  公开（公告）日：2009-04-01

  A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): or a salt thereof, wherein R1 is a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms; R2 is a radioactive halogen substituent; and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimer's disease comprising a compound represented by the above formula or a salt thereof is also provided.

  本研究提供了一种与淀粉样蛋白具有亲和力、能从正常组织中充分快速地清除并能抑制致突变性等毒性的化合物，它由下式（1）表示： 或其盐、 其中，R1 是选自氢、羟基、羧基、硫酸基、氨基、硝基、氰基、1 至 4 个碳原子的烷基取代基或 1 至 4 个碳原子的烷氧基取代基的基团；R2 是放射性卤素取代基；m 是 0 至 2 的整数，还提供了一种低毒的阿尔茨海默病诊断剂，该诊断剂由上式表示的化合物或其盐组成。
• US8277777B2
  申请人：——

  公开号：US8277777B2

  公开（公告）日：2012-10-02
• COMPOUND HAVING AFFINITY FOR AMYLOID
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：EP2042501B1

  公开（公告）日：2017-04-12