3-methyl-indole-2,5-dicarboxylic acid diethyl ester | 132371-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-methyl-indole-2,5-dicarboxylic acid diethyl ester
• 英文别名: 3-Methyl-indol-2,5-dicarbonsaeure-diaethylester；diethyl 3-methyl-1H-indole-2,5-dicarboxylate
• CAS: 132371-72-3
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: UWUQWMHFYGZUMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methyl-indole-2,5-dicarboxylic acid diethyl ester 在 氢氧化钾 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 45.0h， 生成 5,5'-(3-methyl-1H-indole-2,5-diyl)bis(1,3,4-oxadiazole-2(3H)-thione)
  参考文献：
  名称：

  Hiremath; Shivaramayya; Sekhar, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 12, p. 1118 - 1124

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(1-ethoxycarbonyl-propylidenehydrazino)-benzoic acid ethyl ester 在 盐酸 作用下， 生成 3-methyl-indole-2,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Hughes; Lions, Journal and Proceedings - Royal Society of New South Wales, 1937, vol. 71, p. 475,482

  摘要：

  DOI：

文献信息

• HIREMATH, S. P.;SHIVARAMAYYA, K.;SEKHAR, K. RAJA;PUROHIT, M. G., INDIAN. J. CHEM. B, 29,(1990) N2, C. 1118-1124
  作者：HIREMATH, S. P.、SHIVARAMAYYA, K.、SEKHAR, K. RAJA、PUROHIT, M. G.

  DOI：——

  日期：——
• COMPOUNDS POSSESSING ANTIBACTERIAL, ANTIFUNGAL OR ANTITUMOR ACTIVITY
  申请人：GENELABS TECHNOLOGIES, INC.

  公开号：EP1294713A2

  公开（公告）日：2003-03-26
• [EN] NOVEL COMPOUNDS POSSESSING ANTIBACTERIAL, ANTIFUNGAL OR ANTITUMOR ACTIVITY<br/>[FR] NOUVEAUX COMPOSES POSSEDANT UNE ACTIVITE ANTI-BACTERIENNE, ANTIFONGIQUE ET ANTI-TUMEUR
  申请人：GENELABS TECH INC

  公开号：WO2002000650A2

  公开（公告）日：2002-01-03

  The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): wherein: Z?1 and Z2¿ are independently-NR3-(wherein R3 is hydrogen or alkyl) or -O-; R?1 and R2¿ are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R?1 and R2¿ is a group that can form a pharmaceutically acceptable acid addition salt; R3 is hydrogen, alkyl or R?3 and R1 or R2¿ together with the atoms to which they are attached form a heterocyclic ring; X2 is aryl, substituted aryl, heteroaryl, substituded heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic; X?1 and X3¿ are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or-CHR4, wherein R4 is natural or unnatural amino acid side chain; or a pharmaceutically acceptable acid addition salt thereof.Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
• [EN] POLYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL, ANTIFUNGAL OR ANTITUMOR ACTIVITY<br/>[FR] DERIVES DE POLYAMIDE POSSEDANT UNE ACTIVITE ANTIBACTERIENNE, ANTIFONGIQUE OU ANTITUMORALE
  申请人：GENELABS TECH INC

  公开号：WO2003057212A1

  公开（公告）日：2003-07-17

  The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): (I)Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
• Hughes; Lions, Journal and Proceedings - Royal Society of New South Wales, 1937, vol. 71, p. 475,482
  作者：Hughes、Lions

  DOI：——

  日期：——