1-(pentyloxy)-2-propanone | 82160-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(pentyloxy)-2-propanone
• 英文别名: 1-Pentoxypropan-2-one
• CAS: 82160-79-0
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: YKHUVBGFDWEPTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氰乙酸乙酯 、 1-(pentyloxy)-2-propanone 在 吗啉 、 sulfur 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以63%的产率得到2-Amino-4-methyl-5-pentyloxy-thiophene-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  The synthesis of 5-alkoxy and 5-amino substituted thiophenes

  摘要：

  5-Alkoxythiophenes have been prepared by an extension of the Gewald thiophene synthesis and a novel four component condensation reaction uncovered by which 5-aminothiophenes have been prepared. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02338-2
• 作为产物：
  描述：

  1-(pentyloxy)propan-2-ol 在 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 三氯异氰尿酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以96.08 g的产率得到1-(pentyloxy)-2-propanone
  参考文献：
  名称：

  [EN] EMULSIFIABLE CONCENTRATES
  [FR] CONCENTRÉS ÉMULSIFIABLES

  摘要：

  本发明实施例涉及可用作农业工业中乳化浓缩物的组合物。在一方面，该组合物包括（a）至少一种可溶于Ν，Ν-二烷基脂肪酰胺，芳香酮，烷基酮，环状酮或芳香烃溶剂的化合物，其重量百分比为5％或更多；和（b）根据本文所述的公式1的醚酮溶剂，其中R1是具有4至8个碳原子的线性或支链烷基，R2是CH3或CH2CH3，x为0，1或2，当R2为CH3时，R3为CH3，当R2为CH2CH3时，R3为CH2CH3。

  公开号：

  WO2019212803A1

文献信息

• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR
  申请人：Arvinas, Inc.

  公开号：US20160214972A1

  公开（公告）日：2016-07-28

  The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds Androgen Receptor such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of Androgen Receptor.

  本发明涉及双功能化合物，其可用于降解和（抑制）雄激素受体。具体而言，本发明涉及含有一端结合到泛素连接酶的VHL配体和另一端结合雄激素受体的基团的化合物，使得雄激素受体靠近泛素连接酶，从而使雄激素受体发生降解（和抑制）。本发明展现了广泛的药理活性，与本发明的化合物的降解/抑制雄激素受体的作用一致。
• COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS
  申请人：Arvinas, Inc.

  公开号：US20160272639A1

  公开（公告）日：2016-09-22

  The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

  本发明涉及双功能化合物，其作为靶向泛素化的调节剂具有实用性，特别是本发明的双功能化合物可以抑制多种蛋白质和其他蛋白质，这些蛋白质通过本发明的双功能化合物被降解和/或被抑制。具体而言，本发明涉及一端含有结合泛素连接酶的VHL配体，另一端含有结合靶蛋白的基团，使得靶蛋白靠近泛素连接酶，从而降解（和抑制）该蛋白质。本发明展示了与本发明化合物相关的广泛的药理活性，与靶向多肽的降解/抑制一致。
• IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20150291562A1

  公开（公告）日：2015-10-15

  The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  该描述涉及基于亚醰基的化合物，包括包含它们的双官能团化合物，这些化合物在靶向泛素化调节中发挥作用，特别是根据本发明的双官能团化合物抑制各种多肽和其他蛋白质的降解和/或抑制。具体来说，该描述提供了一种化合物，其中一端含有与小脑素E3泛素连接酶结合的配体，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶，以实现该蛋白的降解（和抑制）。可以合成表现出与几乎任何类型的靶向多肽的降解/抑制一致的广泛药理活性的化合物。
• EMULSIFIABLE CONCENTRATES
  申请人：Dow Global Technologies, LLC

  公开号：EP3787402A1

  公开（公告）日：2021-03-10
• Ghrelin Mimetic Polypeptide Hapten Immunoconjugates Having Improved Solubility and Immunogenicity and Methods of Use Thereof
  申请人：Janda Kim D.

  公开号：US20140086949A1

  公开（公告）日：2014-03-27

  Immunoconjugates for impeding weight gain and treating obesity in a subject are disclosed. The immunoconjugates comprise a ghrelin mimetic polypeptide hapten, a spacer moiety comprising one of more polyethylene glycol (PEG) units, and a protein carrier moiety. Immunoconjugates optionally include a conjugation moiety for conjugating the polypeptide hapten with a linker moiety or the protein carrier moiety and a linker moiety for conjugating the conjugation moiety with the protein carrier moiety.