(R)-N-(6-cyano-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-5-(2-methoxyethylamino)-1H-indole-2-carboxamide | 1107650-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (R)-N-(6-cyano-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-5-(2-methoxyethylamino)-1H-indole-2-carboxamide
• 英文别名: N-[(1R)-6-cyano-2,2-dimethyl-1,3-dihydroinden-1-yl]-5-(2-methoxyethylamino)-1H-indole-2-carboxamide
• CAS: 1107650-40-7
• 化学式: C₂₄H₂₆N₄O₂
• 分子量: 402.496
• InChiKey: OWXQVPGMLBEFBW-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-5-amino-N-(6-cyano-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-indole-2-carboxamide 、 甲氧基乙醛 在 碳酸氢钠 、 乙酸乙酯 、 Brine 、 magnesium sulfate 作用下， 以 Tetrahydrofurane dichloromethane 为溶剂， 反应 4.0h， 以The desired product (27.1 mg, 35% yield) was isolated as a pale yellow solid by prep的产率得到(R)-N-(6-cyano-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-5-(2-methoxyethylamino)-1H-indole-2-carboxamide
  参考文献：
  名称：

  Indole indane amide compounds useful as CB2 agonists and method

  摘要：

  本发明提供了具有以下结构的CB2激动剂吲哚吲烷酰胺，其中R1、R2、R3、R4和R5如本文所定义，这些化合物在治疗自身免疫性疾病、炎症、疼痛、心血管疾病和其他通过CB2受体介导的疾病中有用。本发明还提供了一种利用本发明中的化合物预防或治疗这些疾病的方法。

  公开号：

  US07943658B2

文献信息

• INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD
  申请人：Liu Chunjian

  公开号：US20090041722A1

  公开（公告）日：2009-02-12

  Indole indane amides which are CB2 agonists are provided which have the structure wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein, which compounds are useful in treating autoimmune diseases, inflammation, pain, cardiovascular disorders and other diseases mediated by CB2 receptors. A method for preventing or treating such diseases employing the compounds of the invention is also provided.

  提供了一种具有以下结构的CB2受体激动剂吲哚吲哟酰胺，其中R1、R2、R3、R4和R5如本文所定义，这些化合物在治疗自身免疫疾病、炎症、疼痛、心血管疾病以及其他CB2受体介导的疾病中具有用处。还提供了一种利用本发明化合物预防或治疗这些疾病的方法。
• US7943658B2
  申请人：——

  公开号：US7943658B2

  公开（公告）日：2011-05-17
• [EN] INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD<br/>[FR] COMPOSÉS INDOLE INDANE AMIDE UTILES COMME AGONISTES DE CB2 ET PROCÉDÉ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009015169A1

  公开（公告）日：2009-01-29

  Indole indane amides which are CB2 agonists are provided which have the structure I wherein R1, R2, R3, R4 and R5 are as defined herein, which compounds are useful in treating autoimmune diseases, inflammation, pain, cardiovascular disorders and other diseases mediated by CB2 receptors. A method for preventing or treating such diseases employing the compounds of the invention is also provided.
• Indole indane amide compounds useful as CB2 agonists and method
  申请人：Bristol-Myers Squibb Company

  公开号：US07943658B2

  公开（公告）日：2011-05-17

  Indole indane amides which are CB2 agonists are provided which have the structure wherein R1, R2, R3, R4 and R5 are as defined herein, which compounds are useful in treating autoimmune diseases, inflammation, pain, cardiovascular disorders and other diseases mediated by CB2 receptors. A method for preventing or treating such diseases employing the compounds of the invention is also provided.

  本发明提供了具有以下结构的CB2激动剂吲哚吲烷酰胺，其中R1、R2、R3、R4和R5如本文所定义，这些化合物在治疗自身免疫性疾病、炎症、疼痛、心血管疾病和其他通过CB2受体介导的疾病中有用。本发明还提供了一种利用本发明中的化合物预防或治疗这些疾病的方法。