1-propoxy-butan-2-one | 134272-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-propoxy-butan-2-one
• 英文别名: 1-Propyloxy-butanon-(2)；1-Propoxy-butan-2-on；n-propoxy-2-butanone；1-Propoxybutan-2-one
• CAS: 134272-77-8
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: RQZUOMQUAOCTBR-UHFFFAOYSA-N

物化性质

• 沸点：
  56 °C(Press: 4 Torr)
• 密度：
  0.8940 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-propoxy-butan-2-one 在 sodium hydroxide 作用下， 生成 2-ethyl-3-propoxy-quinoline
  参考文献：
  名称：

  Synthesis of 2,3-Disubstituted Cinchoninic Acids from Propoxymethyl Alkyl (or Phenyl) Ketones by Means of the Pfitzinger Reaction¹

  摘要：

  DOI：

  10.1021/ja01188a003

文献信息

• DIHYDROXYACETONE MONOETHERS
  申请人：Buehle Philipp

  公开号：US20130272978A1

  公开（公告）日：2013-10-17

  The present invention relates to the use of dihydroxyacetone monoethers as self-tanning substance, to preparations comprising dihydroxyacetone monoethers, and to certain dihydroxyacetone monoethers and to a process for the preparation thereof.

  本发明涉及将二羟基丙酮单醚用作自然晒黑物质，涉及含有二羟基丙酮单醚的制剂，涉及某些二羟基丙酮单醚以及其制备方法。
• TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
  申请人：AMGEN INC.

  公开号：US20140235642A1

  公开（公告）日：2014-08-21

  Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  式I的化合物可用作TRPM8的拮抗剂。这些化合物对治疗多种TRPM8介导的疾病和症状有用，并可用于制备治疗这些疾病和症状的药物和制剂。这些疾病的例子包括但不限于偏头痛和神经病性疼痛。式I的化合物具有以下结构:其中变量的定义在此提供。
• Verfahren zur Verbesserung der Lagerfähigkeit flüssiger Hydroxy- und Alkoxyalkylketone
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP0764625A1

  公开（公告）日：1997-03-26

  Verfahren zur Verbesserung der Lagerfähigkeit flüssiger Hydroxy- und Alkoxyalkylketone, indem man 0,0001 bis 1 Gew.-% einer Base zusetzt.

  通过添加 0.0001 至 1%（按重量计）的碱来提高液态羟基和烷氧基烷基酮储存稳定性的工艺。
• 5-Alkyl (or 5-Phenyl)-5-propoxymethylhydantoins¹
  作者：Henry R. Henze、Joe W. Melton、Eugene O. Forman

  DOI：10.1021/ja01187a040

  日期：1948.7
• NOVEL CROSS-LINKED PEPTIDES CONTAINING NON-PEPTIDE CROSS-LINKED STRUCTURE, METHOD FOR SYNTHESIZING CROSS-LINKED PEPTIDES, AND NOVEL ORGANIC COMPOUND USED IN METHOD
  申请人：JITSUBO Co., Ltd.

  公开号：US20160333052A1

  公开（公告）日：2016-11-17

  The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.