3-Methoxy-5-phenylacetophenone | 1073642-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Methoxy-5-phenylacetophenone
• 英文别名: 1-(3-methoxy-5-phenylphenyl)ethanone
• CAS: 1073642-78-0
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.27
• InChiKey: ZLLGHUMRZLIUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC ANALOGS OF PROPARGYL-LINKED INHIBITORS OF DIHYDROFOLATE REDUCTASE
  申请人：University of Connecticut

  公开号：EP2776404B1

  公开（公告）日：2016-07-06
• US8426432B2
  申请人：——

  公开号：US8426432B2

  公开（公告）日：2013-04-23
• US8853228B2
  申请人：——

  公开号：US8853228B2

  公开（公告）日：2014-10-07
• [EN] HETEROCYCLIC ANALOGS OF PROPARGYL-LINKED INHIBITORS OF DIHYDROFOLATE REDUCTASE<br/>[FR] ANALOGUE HÉTÉROCYCLIQUE D'INHIBITEURS DU DIHYDROFOLATE LIÉS À PROPARGYLE RÉDUCTASE
  申请人：UNIV CONNECTICUT

  公开号：WO2013070620A1

  公开（公告）日：2013-05-16

  The compositions and methods described herein disclose the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus, fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii. These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.