diethyleneglycol di-n-hexyl ether | 68191-03-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diethyleneglycol di-n-hexyl ether
• 英文别名: Bis(2-hexyloxy-ethyl) ether；1-[2-(2-hexoxyethoxy)ethoxy]hexane
• CAS: 68191-03-7
• 化学式: C₁₆H₃₄O₃
• 分子量: 274.444
• InChiKey: QRUDYUQVHZEMPL-UHFFFAOYSA-N

物化性质

• 沸点：
  338.3±17.0 °C(Predicted)
• 密度：
  0.880±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溴己烷 、 二乙二醇 生成 diethyleneglycol di-n-hexyl ether
  参考文献：
  名称：

  将二甘醇二正烷基醚与二甘醇二甲醚或正构烷烃混合时的焓和体积变化

  摘要：

  将二甘醇二正烷基醚（烷基-氧乙烯-烷基三嵌段低聚物）与二甘醇二甲醚[oligo（oxyethylene）]或C 12，C 14和C 16正构烷烃混合时的焓和体积变化在31°C下测量。将这些假二元混合物的结果与二元体系（即低聚（氧乙烯）s +正构烷烃）的结果进行比较。

  DOI：

  10.1039/f19858100223

文献信息

• Enthalpy and volume changes on mixing diethylene glycol di-n-alkyl ethers with diethylene glycol dimethyl ether or n-alkanes
  作者：Jawad K. H. Al-Kafaji、Zaitun Ariffin、Jeremy Cope、Colin Booth

  DOI：10.1039/f19858100223

  日期：——

  Enthalpy and volume changes on mixing diethylene glycol di-n-alkyl ethers (alkyl–oxyethylene–alkyl triblock oligomers) with either diethylene glycol dimethyl ether [oligo(oxyethylene)] or the C12, C14 and C16 n-alkanes have been measured at 31 °C. The results for these pseudo-binary mixtures are compared with those for binary systems, i.e. oligo-(oxyethylene)s + n-alkanes.

  将二甘醇二正烷基醚（烷基-氧乙烯-烷基三嵌段低聚物）与二甘醇二甲醚[oligo（oxyethylene）]或C 12，C 14和C 16正构烷烃混合时的焓和体积变化在31°C下测量。将这些假二元混合物的结果与二元体系（即低聚（氧乙烯）s +正构烷烃）的结果进行比较。
• Process for the preparation of cyclic esters and method for purification of the same
  申请人：——

  公开号：US20030191326A1

  公开（公告）日：2003-10-09

  The present invention provides a process for production of a cyclic ester by depolymerization of an aliphatic polyester. In the process, a mixture containing the aliphatic polyester and a specific polyalkylene glycol ether, which has a boiling point of 230-450° C. and a molecular weight of 150-450, is heated under normal or reduced pressure to a temperature at which depolymerization of the aliphatic polyester takes place. Then, a substantially homogeneous solution phase, consisting of the melt phase of the aliphatic polyester and the liquid phase of the polyalkylene glycol ether, is formed. Heating of the solution phase is continued to form the cyclic ester by depolymerization and distil out the cyclic ester together with the polyalkylene glycol ether, and then the cyclic ester is recovered from the distillate. The present invention also provides a process for purification of a crude cyclic ester by use of the specific polyalkylene glycol ether described above.

  本发明提供了一种通过脂肪族聚酯的降解来生产环酯的方法。在该过程中，将含有脂肪族聚酯和具有沸点在230-450°C和分子量在150-450之间的特定聚烷基乙二醇醚的混合物，在常压或减压下加热至脂肪族聚酯发生降解的温度。然后，形成由脂肪族聚酯的熔融相和聚烷基乙二醇醚的液相组成的基本均相溶液相。继续加热溶液相以通过降解形成环酯并与聚烷基乙二醇醚一起蒸馏出环酯，然后从馏出物中回收环酯。本发明还提供了一种利用上述特定聚烷基乙二醇醚对粗环酯进行纯化的方法。
• [EN] PROTEOLYSIS TARGETING CHIMERA COMPOUNDS AND METHODS OF PREPARING AND USING SAME<br/>[FR] COMPOSÉS CHIMÈRES DE CIBLAGE DE PROTÉOLYSE ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
  申请人：UNIV YALE

  公开号：WO2017079267A1

  公开（公告）日：2017-05-11

  The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.

  本发明涉及新型化合物和方法，用于预防或治疗与主题需要的酪氨酸激酶过度表达和/或无控制激活相关和/或引起的疾病。在某些实施例中，本发明的化合物包括酪氨酸激酶抑制剂、连接剂和泛素连接酶结合剂。本发明的方法包括向主题给予本发明中至少一种化合物的药物有效量。
• METHOD FOR PRODUCING a-HYDROXYCARBOXYLIC ACID DIMERIC CYCLIC ESTER
  申请人：Kureha Corporation

  公开号：US20190330175A1

  公开（公告）日：2019-10-31

  Provided is a method for producing a high purity α-hydroxycarboxylic acid dimeric cyclic ester while heavy-component formation from an α-hydroxycarboxylic acid oligomer is suppressed. An α-hydroxycarboxylic acid dimeric cyclic ester is obtained by performing a depolymerization reaction in the coexistence of an inorganic acid or an inorganic acid salt or a mixture thereof; and an organophosphorus compound.

  提供了一种制备高纯度α-羟基羧酸二聚环酯的方法，同时抑制从α-羟基羧酸寡聚体中形成重组分。通过在无机酸或无机酸盐或二者混合物的共存下进行解聚反应，并加入有机磷化合物，可以得到α-羟基羧酸二聚环酯。
• METHOD FOR PRODUCING CYCLIC ESTER
  申请人：Kureha Corporation

  公开号：US20200392102A1

  公开（公告）日：2020-12-17

  In a method for producing a cyclic ester according to an embodiment of the present invention, a mixture (I) containing an aliphatic polyester, a specific polyalkylene glycol diether, and a sulfonic acid compound as a thermal stabilizer is prepared and heated in predetermined conditions to obtain a mixture (II) in a state of solution. Furthermore, heating of the mixture (II) is continued to distill, together with the polyalkylene glycol diether, a cyclic ester formed by the depolymerization reaction, and thus a distillate (III) is obtained. The cyclic ester is recovered from the distillate (III). At this time, a specific solubilizing agent is added to at least one of the mixture (I) or (II). In this production method, the sulfonic acid compound as the thermal stabilizer is contained in the mixtures (I) and (II) and the distillate (III).

  根据本发明实施例的一种制备环酯的方法中，制备含有脂肪族聚酯、特定聚烷基醚二醇和磺酸化合物作为热稳定剂的混合物(I)，并在预定条件下加热，得到处于溶液状态的混合物(II)。此外，继续加热混合物(II)以蒸馏，与聚烷基醚二醇一起蒸馏出由去聚合反应形成的环酯，从而得到馏出物(III)。从馏出物(III)中回收环酯。此时，在混合物(I)或(II)中至少添加一种特定的溶解剂。在此生产方法中，磺酸化合物作为热稳定剂被包含在混合物(I)、(II)和馏出物(III)中。