4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde | 943767-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde
• 英文别名: 4-(2,2,3,3,3-pentafluoropropyloxy) benzaldehyde；4-(2,2,3,3,3-Pentafluoropropoxy)benzaldehyde
• CAS: 943767-49-5
• 化学式: C₁₀H₇F₅O₂
• 分子量: 254.156
• InChiKey: BFPWBUNMCHTROS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde 、 (R)-2-(氨甲基)-1-BOC-吡咯烷 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,1-二氯乙烷 为溶剂， 反应 17.0h， 生成 1,1-dimethylethyl 2-[[[[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]methyl]amino]methyl]-1-pyrrolidinecarboxylate
  参考文献：
  名称：

  Diamine derivatives as inhibitors of leukotriene A4 hydrolase

  摘要：

  这项发明涉及式(I)的化合物： 其中r、q、R、R2、R3、R4、R5a、R5b、R5c、R6a、R6b、R6c、R7、R8和R9如本文所述，可以是单一立体异构体或立体异构体混合物，或其药学上可接受的盐、溶剂合物、包合物、多型体、铵离子、N-氧化物或其前药；这些化合物是白三烯A4水解酶抑制剂，因此在治疗炎症性疾病中有用。还公开了包括该发明化合物的药物组合物以及制备该发明化合物的方法。

  公开号：

  US20070155726A1
• 作为产物：
  描述：

  1H,1H-五氟对甲苯磺酸丙酯 、 对羟基苯甲醛 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.5h， 生成 4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde
  参考文献：
  名称：

  Diamine derivatives as inhibitors of leukotriene A4 hydrolase

  摘要：

  这项发明涉及式(I)的化合物： 其中r、q、R、R2、R3、R4、R5a、R5b、R5c、R6a、R6b、R6c、R7、R8和R9如本文所述，可以是单一立体异构体或立体异构体混合物，或其药学上可接受的盐、溶剂合物、包合物、多型体、铵离子、N-氧化物或其前药；这些化合物是白三烯A4水解酶抑制剂，因此在治疗炎症性疾病中有用。还公开了包括该发明化合物的药物组合物以及制备该发明化合物的方法。

  公开号：

  US20070155726A1

文献信息

• DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
  申请人：Celtaxsys, Inc.

  公开号：US20150080382A1

  公开（公告）日：2015-03-19

  This invention is directed to compounds of formula (I): where r, q, R, R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 6a , R 6b , R 6c , R 7 , R 8 , and R 9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A 4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

  该发明涉及式（I）的化合物：其中r、q、R、R2、R3、R4、R5a、R5b、R5c、R6a、R6b、R6c、R7、R8和R9如本文所述，作为单一立体异构体或立体异构体混合物，或其药学上可接受的盐、溶剂化合物、包合物、多晶体、铵离子、N-氧化物或其前药；这些化合物是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。本发明还公开了包含该化合物的制药组合物以及制备该化合物的方法。
• Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase
  申请人：Arnaiz Damian

  公开号：US20100210630A1

  公开（公告）日：2010-08-19

  This invention is directed to compounds of formula (I): where r, q, R, R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 6a , R 6b , R 6c , R 7 , R 8 , and R 9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A 4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

  本发明涉及化合物的公式(I)：其中r、q、R、R2、R3、R4、R5a、R5b、R5c、R6a、R6b、R6c、R7、R8和R9如本文所述，可以作为单一立体异构体或立体异构体混合物，或其药学上可接受的盐、溶剂合物、包合物、多晶体、铵离子、N-氧化物或前药；这些化合物是白三烯A4水解酶抑制剂，因此在治疗炎症性疾病方面有用。本发明还公开了包含该化合物的制药组合物以及制备该化合物的方法。
• CHEMICALLY ADSORBABLE SUBSTANCE FOR THIN FILM FORMATION AND PROCESS FOR PRODUCING THE SAME
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP1130072A1

  公开（公告）日：2001-09-05

  A thin film forming chemical adsorption material of the present invention includes at least a functional group expressed by the following chemical formula and a -SiX group (X represents halogen) as an end group bonded by siloxane bond. Consequently, a novel, thin-film forming, chemical adsorption material which is capable of forming a thin-film of a monomolecular layer form and has photosensitive groups which are transparent and stable in a visible light region and cause photochemical reaction in a ultraviolet light region, and the producing method thereof can be provided. The liquid crystal alignment film of the present invention includes an aggregation of adsorption molecules chemically adsorbed directly on a surface of a substrate with electrodes or chemically adsorbed indirectly thereon through another material layer, and further the adsorption molecules include adsorption molecule having a characteristic group expressed by the following chemical formula and a -O-Si bond group at a molecular end group. Consequently, the liquid crystal alignment film that is uniformly and strongly anchored on the substrate, is excellent in thermal stability of alignment as well as in controllability of alignment, and has a film thickness of such a level of nanometer as to be produced with good productivity, and the LCD using the same can be provided.

  本发明的一种形成薄膜的化学吸附材料至少包括一个由以下化学式表示的官能团和一个-SiX基团（X代表卤素），作为通过硅氧烷键结合的端基。因此，本发明提供了一种新型的、可形成单分子层状薄膜的、具有光敏基团的、在可见光区透明且稳定、在紫外光区可引起光化学反应的、可形成薄膜的化学吸附材料及其生产方法。 本发明的液晶配向膜包括直接化学吸附在带电极的基底表面上或通过另一材料层间接化学吸附在基底表面上的吸附分子的聚集体，吸附分子还包括具有以下化学式表示的特征基团的吸附分子和分子末端基团上的-O-Si 键基团。因此，可以提供均匀而牢固地固定在基板上的液晶配向膜，其配向热稳定性和配向可控性都很好，膜厚为纳米级，可以以良好的生产率生产，并可以提供使用该膜的液晶显示器。
• EP3205644A1
  申请人：——

  公开号：EP3205644A1

  公开（公告）日：2017-08-16
• US6524715B1
  申请人：——

  公开号：US6524715B1

  公开（公告）日：2003-02-25