1-chloro-4-(2-fluoroethoxy)benzene | 405-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-chloro-4-(2-fluoroethoxy)benzene
• CAS: 405-72-1
• 化学式: C₈H₈ClFO
• 分子量: 174.602
• InChiKey: PCTXTRGQXOZUBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-氯苯氧)乙醇 在 potassium fluoride 、 N-苯基双(三氟甲烷磺酰)亚胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以67%的产率得到1-chloro-4-(2-fluoroethoxy)benzene
  参考文献：
  名称：

  以 KF 为氟源的醇直接脱氧氟化

  摘要：

  本报告描述了一种以 KF 作为氟源通过原位生成高活性 CF 3 SO 2 F 的醇脱氧氟化的方法。包括卤素、硝基、酮、酯、烯烃和炔烃在内的多种官能团具有良好的耐受性。温和的条件、短的反应时间和广泛的底物范围使该方法成为构建 C-F 键的绝佳选择。

  DOI：

  10.1021/acs.joc.2c00388

文献信息

• Direct Deoxyfluorination of Alcohols with KF as the Fluorine Source
  作者：Jun Xu、Chao Peng、Bolin Yao、Hua-Jian Xu、Qiang Xie

  DOI：10.1021/acs.joc.2c00388

  日期：2022.5.6

  This report describes a method for the deoxyfluorination of alcohols with KF as the fluorine source via in situ generation of highly active CF3SO2F. Diverse functionalities, including halogen, nitro, ketone, ester, alkene, and alkyne, are well tolerated. Mild conditions, a short reaction time, and a wide substrate scope make this method an excellent choice for the construction of C–F bonds.

  本报告描述了一种以 KF 作为氟源通过原位生成高活性 CF 3 SO 2 F 的醇脱氧氟化的方法。包括卤素、硝基、酮、酯、烯烃和炔烃在内的多种官能团具有良好的耐受性。温和的条件、短的反应时间和广泛的底物范围使该方法成为构建 C-F 键的绝佳选择。
• A Structural Equation Model of Parental Involvement, Motivational and Aptitudinal Characteristics, and Academic Achievement
  作者：Julio Antonio Gonzalez-pienda、Jose Carlos Nunez、Soledad Gonzalez-pumariega、Luis Alvarez、Cristina Roces、Marta Garcia

  DOI：10.1080/00220970209599509

  日期：2002.1

  The authors used the structural equation model (SEM) approach to test a model hypothesizing the influence of parental involvement on students' academic aptitudes, self-concept, and causal attributions, as well as the influence of the 3 variables on academic achievement. The theoretical model was contrasted in a group of 12- to 18-year-old adolescents (N = 261) attending various educational centers. The results indicate that (a) parental involvement had a positive and significant influence on the participant's measured characteristics; (b) causal attribution was not causally related to self-concept or academic achievement when the task involved finding causes for success, but, self-concept and causal attributions were found to be significantly and reciprocally related when the task involved finding causes accounting for failure; (c) self-concept was statistically and predominantly causally related to academic achievement, but not vice versa; and (d) aptitude and self-concept accounted for academic achievement, although the effect of self-concept was predominant. These results suggest that in adolescence, cognitive-affective variables become crucial in accounting for academic behavior.
• Divergent dehydroxyfluorination and carbonation of alcohols with trifluoromethyl trifluoromethanesulfonate
  作者：Long-Yu Ran、Xue Ding、Xue-Ping Yan、Cheng-Pan Zhang

  DOI：10.1039/d2ob02028a

  日期：——

  Preparation of alkyl fluorides and carbonates via divergent dehydroxyfluorination and carbonation of alcohols with trifluoromethyl trifluoromethanesulfonate (CF3SO2OCF3) is described. The reactions performed with BTMG in THF provided alkyl fluorides in good yields, whereas those of two different alcohols with Et3N in DCM formed asymmetric carbonates in moderate to excellent yields. CF3SO2OCF3 was demonstrated

  描述了通过使用三氟甲磺酸三氟甲酯 (CF 3 SO 2 OCF 3 )对醇进行不同的脱羟基氟化和碳酸化来制备烷基氟化物和碳酸酯。在 THF 中使用 BTMG 进行的反应以良好的收率提供烷基氟化物，而在 DCM 中使用 Et 3 N 的两种不同醇的反应以中等到极好的收率形成不对称碳酸酯。CF 3 SO 2 OCF 3通过改变碱基，在反应中被证明是“F”或“CO”试剂，允许从相应的醇中高效地选择性构建烷基氟化物和碳酸酯。值得注意的是，该方法综合制备了其他方法难以合成的含氟不对称碳酸酯，在学术和工业领域都具有巨大的应用潜力。