1,1-diethoxy-4-methyl-pentan-2-one | 56830-23-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-diethoxy-4-methyl-pentan-2-one
• 英文别名: 1,1-Diaethoxy-4-methyl-pentan-2-on；Isobutylglyoxal-diaethylacetal；1,1-Diethoxy-4-methylpentan-2-one
• CAS: 56830-23-0
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.267
• InChiKey: MLTRGSWMWKABDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-diethoxy-4-methyl-pentan-2-one 在 dog's liver-extract 、 硫酸 作用下， 生成 (R)-2-羟基-4-甲基戊酸
  参考文献：
  名称：

  Dakin; Dudley, Journal of Biological Chemistry, 1914, vol. 18, p. 38

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 1,1-diethoxy-4-methyl-pentan-2-one
  参考文献：
  名称：

  Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae

  摘要：

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.

  DOI：

  10.1111/j.1749-7345.2001.tb01091.x

文献信息

• A practical total synthesis of plaunotol via highly Z-selective Wittig olefination of α-acetal ketones
  作者：Keiko Tago、Masami Arai、Hiroshi Kogen

  DOI：10.1039/b001977l

  日期：——

  Helicobacter pylori, a causative agent in gastric ulcers and gastric adenocarcinoma, for example. In our investigation of the practical synthesis of 1, we have developed an efficient method for stereoselective synthesis of trisubstituted olefins via a Z-selective Wittig reaction. The olefination of readily available aliphatic α-acetal ketones with triphenylphosphonium salts in the presence of a potassium base

  普劳诺醇（1）已知的抗溃疡药药品，是泰国民间药用植物Plau-noi的最重要成分，它具有显着的抗消化性溃疡活性。最近发现lau草醇（1）具有抗幽门螺杆菌的抗菌活性，幽门螺杆菌是例如胃溃疡和胃腺癌的病原体。在我们对1的实际合成的研究中，我们开发了一种有效的立体选择性合成三取代的方法烯烃 经由一个ž -选择性Wittig反应。易于获得的脂肪族α-缩醛的烯烃化酮类在钾碱和18-冠-6醚存在下，用三苯基salts盐进行Z选择性反应。所述ž -选择性烯为一系列三取代烯烃部分的的结构的有用的方法; 实用的和立体选择性的全合成lau草醇通过该Wittig反应获得了（1）。
• Syntheses and evaluation of the bioluminescent activity of (S)-Cypridina luciferin and its analogs
  作者：Chun Wu、Kosei Kawasaki、Satoru Ohgiya、Yoshihiro Ohmiya

  DOI：10.1016/j.tetlet.2005.11.119

  日期：2006.1

  the presence of Cypridina luciferase was about 1.7 times as active as that of racemic form. Furthermore, several luciferin analogs prepared by the same condensation with different α-ketoacetal derivatives showed moderate light yield with Cypridina luciferase. These readily available Cypridina luciferin and analogs are applicable to the bioluminescent detection of Cypridina luciferase.

  赛氏丝虫萤光素是发光的球形赛氏丝虫（姬菇）hilgendorfii的生物发光的底物。球藻萤光素在仲丁基部分中含有一个手性中心。在这里，我们报告了通过（S）-1,1-二乙氧基-3-甲基戊-2--2-与硫代荧光素的缩合来制备（S）-Cypridina luciferin的简便方法。合成（S荧光素酶荧光素酶的存在下，）-荧光素的活性约为外消旋形式的活性的1.7倍。此外，通过用不同的α-酮缩醛衍生物相同的缩合反应制备的几种荧光素类似物在赛普里迪纳荧光素酶中显示出中等的光产量。这些容易获得的丝藻荧光素和类似物可用于丝藻荧光素酶的生物发光检测。
• Reactivity of primary and secondary N-2-(1,1-dichloroalkylidene)anilines. V
  作者：Norbert De Kimpe、Niceas Schamp

  DOI：10.1021/jo00913a029

  日期：1975.12
• Gallagher et al., Journal of the Chemical Society, 1952, p. 4870,4873
  作者：Gallagher et al.

  DOI：——

  日期：——
• Dakin; Dudley, Journal of Biological Chemistry, 1914, vol. 18, p. 38
  作者：Dakin、Dudley

  DOI：——

  日期：——