7-fluoro-4-hexyl-2-phenyl-9H-pyrido[2,3-b]indole | 1350516-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-fluoro-4-hexyl-2-phenyl-9H-pyrido[2,3-b]indole
• CAS: 1350516-23-2
• 化学式: C₂₃H₂₃FN₂
• 分子量: 346.447
• InChiKey: NOFQYNUYLNMDEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-fluoro-1H-indol-2-amine hydrochloride 、 1-phenyl-2-nonyn-1-one 在 potassium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 2.0h， 生成 7-fluoro-4-hexyl-2-phenyl-9H-pyrido[2,3-b]indole
  参考文献：
  名称：

  Three-Component Tandem Reaction Involving Acid Chlorides, Terminal Alkynes, and 2-Aminoindole Hydrochlorides: Synthesis of α-Carboline Derivatives in Aqueous Conditions via Regioselective [3 + 3] Cyclocondensation

  摘要：

  An efficient synthesis toward highly diversified a-carboline derivatives via a three-component tandem reaction using acid chlorides, terminal allcynes, and 2-aminoindole hydrochlorides has been described. The salient feature of the one-pot strategy involves regioselective [3 + 3]-cyclocondensation and the presence of water in the reaction medium to facilitate cyclizafion. Nonaqueous conditions furnished products in poor yields.

  DOI：

  10.1021/jo201994v

文献信息

• Three-Component Tandem Reaction Involving Acid Chlorides, Terminal Alkynes, and 2-Aminoindole Hydrochlorides: Synthesis of α-Carboline Derivatives in Aqueous Conditions via Regioselective [3 + 3] Cyclocondensation
  作者：Sahaj Gupta、Brijesh Kumar、Bijoy Kundu

  DOI：10.1021/jo201994v

  日期：2011.12.16

  An efficient synthesis toward highly diversified a-carboline derivatives via a three-component tandem reaction using acid chlorides, terminal allcynes, and 2-aminoindole hydrochlorides has been described. The salient feature of the one-pot strategy involves regioselective [3 + 3]-cyclocondensation and the presence of water in the reaction medium to facilitate cyclizafion. Nonaqueous conditions furnished products in poor yields.