The novel intermediate compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the practical synthetic process for preparing β-carotene by the use of the above novel compound are disclosed. The synthesis of β-carotene is characterized by the double elimination reactions of the C
40
compound containing both the benzenesulfonyl group and the group X (either halogen or ether), which can be prepared by the coupling reaction of the novel C
10
dialdehyde with two equivalents of the C
15
allylic sulfone, followed by the functional group transformation of the resulting C
40
diol either to the corresponding halide or to the ether, to produce the fully conjugated polyene chain.
本发明公开了一种新型中间化合物,可高效地用于基于磺酰
化学的类
胡萝卜素化合物的合成,以及其制备方法和利用上述新型化合物制备
β-胡萝卜素的实际合成过程。
β-胡萝卜素的合成以含有苯磺酰基和X基团(卤素或醚)的C40化合物的双消除反应为特征,该化合物可通过新型C10二醛与两当量的C15烯丙基磺酰化合物的偶联反应制备,并通过所得C40二醇的官能团转化为相应的卤化物或醚,以产生完全共轭的多烯链。