5-((diethylamino)methyl)thiazol-2-amine | 944401-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-((diethylamino)methyl)thiazol-2-amine
• 英文别名: 5-(diethylaminomethyl)-1,3-thiazol-2-amine
• CAS: 944401-97-2
• 化学式: C₈H₁₅N₃S
• 分子量: 185.293
• InChiKey: VYNGLKMVBHCVQB-UHFFFAOYSA-N

物化性质

• 沸点：
  285.4±15.0 °C(Predicted)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  70.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-醛基噻唑 、 二乙胺 在 sodium cyanoborohydride 、 水 作用下， 以 甲醇 为溶剂， 反应 10.0h， 生成 5-((diethylamino)methyl)thiazol-2-amine
  参考文献：
  名称：

  WO2007/84786

  摘要：

  公开号：

文献信息

• PYRIMIDINE DERIVATIVES USED AS PI-3-KINASE INHIBITORS
  申请人：Burger Matthew

  公开号：US20100249126A1

  公开（公告）日：2010-09-30

  Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

  磷脂鞘氨醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药；新化合物的组合物，可单独使用或与至少一种额外治疗剂联合使用，与药学上可接受的载体；以及新化合物的用途，可单独使用或与至少一种额外治疗剂联合使用，用于预防或治疗通过生长因子、蛋白质丝氨酸/苏氨酸激酶和磷脂酰肌醇激酶异常活性所表现的增殖性疾病。
• PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS
  申请人：BURGER Matthew

  公开号：US20120225859A1

  公开（公告）日：2012-09-06

  Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

  磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药；新化合物的组合物，可以单独使用或与至少一种额外治疗剂联合使用，以药学上可接受的载体为基础；新化合物的用途，可以单独使用或与至少一种额外治疗剂联合使用，用于预防或治疗增殖性疾病，其特征是生长因子，蛋白丝氨酸/苏氨酸激酶和磷脂酰肌醇激酶的异常活性。
• NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME
  申请人：KOWA COMPANY, LTD.

  公开号：US20140309207A1

  公开（公告）日：2014-10-16

  The present invention provides a novel compound represented by a general formula (1) as shown below, which has a glucokinase-activating action in the liver and pancreatic β-cells and which is useful as an agent for preventing and/or treating diseases caused by hyperglycemia, such as diabetes. A spiroindoline compound represented by the general formula (1), or a salt thereof, or a solvate of the compound or the salt: [wherein ring A represents a nitrogen-containing 5-10 membered heteroaryl group; R 1 and R 2 , which are the same or different, each represent a hydrogen atom, a halogen atom, a halo C 1-6 alkyl group, a C 6-10 aryl group, a cyano group, a C 1-6 alkyl group optionally having a substituent, a C 2-6 alkenyl group optionally having a substituent, etc.; R 3 represents a hydrogen atom, a C 1-6 alkyl group optionally having a substituent, etc.; and R 4 represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group optionally having a substituent, etc.]

  本发明提供了一种新型化合物，其通式（1）如下所示，具有在肝脏和胰岛β细胞中激活葡萄糖激酶的作用，并可用作预防和/或治疗由高血糖引起的疾病，如糖尿病的药物。该通式（1）表示的螺环吲哚化合物，或其盐，或化合物或盐的溶剂：[其中环A代表含氮的5-10成员杂环基；R1和R2，相同或不同，分别代表氢原子，卤原子，卤代C1-6烷基，C6-10芳基，氰基，C1-6烷基，可选取代基，C2-6烯基，可选取代基等；R3代表氢原子，C1-6烷基，可选取代基等；R4代表氢原子，卤原子，C1-6烷基，可选取代基等。]
• Pyrimidine derivatives used as pi-3 kinase inhibitors
  申请人：Novartis AG

  公开号：EP2261223A1

  公开（公告）日：2010-12-15

  Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

  磷脂酰肌醇 (PI) 3- 激酶抑制剂化合物 (I)、其药学上可接受的盐类，与至少一种额外的治疗剂和药学上可接受的载体结合使用；用于预防或治疗以生长因子、蛋白丝氨酸/苏氨酸激酶和磷脂激酶活性异常为特征的增殖性疾病。
• US8217035B2
  申请人：——

  公开号：US8217035B2

  公开（公告）日：2012-07-10