2-[di(1H-indol-3-yl)methyl]-4-(morpholin-4-ylmethyl)phenol | 1014625-20-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[di(1H-indol-3-yl)methyl]-4-(morpholin-4-ylmethyl)phenol
• 英文别名: 2-[bis(1H-indol-3-yl)methyl]-4-(morpholin-4-ylmethyl)phenol
• CAS: 1014625-20-7
• 化学式: C₂₈H₂₇N₃O₂
• 分子量: 437.541
• InChiKey: MWUSJIZVNDONAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  64.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚 、 2-hydroxy-5-[(morpholin-4-yl)methyl]benzaldehyde 在 zinc(II) oxide 作用下， 反应 2.0h， 以61%的产率得到2-[di(1H-indol-3-yl)methyl]-4-(morpholin-4-ylmethyl)phenol
  参考文献：
  名称：

  Synthesis of Bis(indolyl)methanes using a Catalytic Amount of ZnO under Solvent‐Free Conditions

  摘要：

  Efficient electrophilic substitution reactions of indoles with various aromatic aldehydes were carried out using a catalytic amount of ZnO under solvent-free conditions to afford the corresponding bis(indolyl)methanes in excellent yields. Among the various methods published for the synthesis of bis(indolyl)methane, ZnO is a very cheap, environmentally friendly, and reusable catalyst that can be used for synthesis of a new range of bis(indolyl)methane derivatives.

  DOI：

  10.1080/00397910701845274

文献信息

• Synthesis of Bis(indolyl)methanes using a Catalytic Amount of ZnO under Solvent‐Free Conditions
  作者：Mona Hosseini‐Sarvari

  DOI：10.1080/00397910701845274

  日期：2008.2.1

  Efficient electrophilic substitution reactions of indoles with various aromatic aldehydes were carried out using a catalytic amount of ZnO under solvent-free conditions to afford the corresponding bis(indolyl)methanes in excellent yields. Among the various methods published for the synthesis of bis(indolyl)methane, ZnO is a very cheap, environmentally friendly, and reusable catalyst that can be used for synthesis of a new range of bis(indolyl)methane derivatives.