allyl (5S,6S,7S)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate | 136279-53-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: allyl (5S,6S,7S)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate
• 英文别名: prop-2-enyl (1S,2S,3S)-3-[(1R)-1-hydroxyethyl]-4-oxo-10-thia-5-azatricyclo[5.4.0.02,5]undec-6-ene-6-carboxylate
• CAS: 136279-53-3
• 化学式: C₁₅H₁₉NO₄S
• 分子量: 309.386
• InChiKey: DCMVFHKARQHLAU-SASUGWTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  92.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  allyl (5S,6S,7S)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate 在 四(三苯基膦)钯 、 三苯基膦 、 偶氮二甲酸二乙酯 、 sodium 2-ethylhexanoic acid 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 sodium (8S,9R,10E)-1-aza-10-ethylidene-11-oxo-6-thia-tricyclo(7.2.0.0^3,8)undec-2-en-2-carboxylate
  参考文献：
  名称：

  Design, synthesis and bioactivity evaluation of tribactam β lactamase inhibitors

  摘要：

  Known carbapenem compounds with inhibitory effect towards P-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00061-6
• 作为产物：
  描述：

  4-乙酰氧基氮杂环丁酮 在 甲酸 四(三苯基膦)钯 、 四丁基氟化铵 、 sodium hydride 、 溶剂黄146 、 三乙胺 、 对苯二酚 、 三苯基膦 、 亚磷酸三乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 生成 allyl (5S,6S,7S)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate
  参考文献：
  名称：

  Design, synthesis and bioactivity evaluation of tribactam β lactamase inhibitors

  摘要：

  Known carbapenem compounds with inhibitory effect towards P-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00061-6

文献信息

• Synthesis and antibacterial activity of some thio trinems
  作者：Stefano Biondi、Elisabetta Piga、Tino Rossi、Gilberto Vigelli

  DOI：10.1016/s0960-894x(97)00360-0

  日期：1997.8

  The synthesis and antibacterial activity of some trinems having a sulfur atom in various positions of ring C are presented. (C) 1997 Elsevier Science Ltd.
• Design, synthesis and bioactivity evaluation of tribactam β lactamase inhibitors
  作者：Anton Copar、Tadeja Prevec、Borut Anžič、Tomaž Mesar、Lovro Selič、Mateja Vilar、Tom Solmajer

  DOI：10.1016/s0960-894x(02)00061-6

  日期：2002.3

  Known carbapenem compounds with inhibitory effect towards P-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems. (C) 2002 Elsevier Science Ltd. All rights reserved.