(E)-5-chloro-2-(3-(3-fluorophenyl)allyl)phenol | 1432498-23-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-5-chloro-2-(3-(3-fluorophenyl)allyl)phenol
• 英文别名: 5-chloro-2-[(E)-3-(3-fluorophenyl)prop-2-enyl]phenol
• CAS: 1432498-23-1
• 化学式: C₁₅H₁₂ClFO
• 分子量: 262.711
• InChiKey: OQTLCPOYQPAVGQ-HNQUOIGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-1-(4-chloro-2-hydroxyphenyl)-3-(3-fluorophenyl)prop-2-en-1-one 在 sodium tetrahydroborate 、 cerium(III) chloride heptahydrate 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.17h， 生成 (E)-5-chloro-2-(3-(3-fluorophenyl)allyl)phenol
  参考文献：
  名称：

  Deoxygenation of α,β-unsaturated acylphenols through ethyl o-acylphenylcarbonates with Luche reduction

  摘要：

  An efficient protocol for deoxygenation of alpha,beta-unsaturated acylphenols through ethyl o-acylphenylcarbonates with Luche reduction is described. The reaction shows very good selectivity and tolerates a wide range of functionalities on alpha,beta-unsaturated acylphenols, giving corresponding 2-allylphenols in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.02.109

文献信息

• Deoxygenation of α,β-unsaturated acylphenols through ethyl o-acylphenylcarbonates with Luche reduction
  作者：Hu Yuan、Hao Chen、Huizi Jin、Bo Li、Rongcai Yue、Ji Ye、Yunheng Shen、Lei Shan、Qingyan Sun、Weidong Zhang

  DOI：10.1016/j.tetlet.2013.02.109

  日期：2013.5

  An efficient protocol for deoxygenation of alpha,beta-unsaturated acylphenols through ethyl o-acylphenylcarbonates with Luche reduction is described. The reaction shows very good selectivity and tolerates a wide range of functionalities on alpha,beta-unsaturated acylphenols, giving corresponding 2-allylphenols in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.