2-Hydroxymethyl-2-nonyloxirane | 135214-51-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Hydroxymethyl-2-nonyloxirane
• 英文别名: 2-nonyloxiranemethanol；(2-Nonyloxiran-2-yl)methanol
• CAS: 135214-51-6
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: MTZGPCUBNFEIST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Hydroxymethyl-2-nonyloxirane 在 乙酸乙烯酯 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以36%的产率得到(2S)-2-hydroxymethyl-2-nonyloxirane
  参考文献：
  名称：

  Enzymic resolution of 2-substituted oxiranemethanols, a class of synthetically useful building blocks, bearing a chiral quaternary center

  摘要：

  DOI：

  10.1021/jo00018a057
• 作为产物：
  描述：

  1-溴壬烷 在 vanadium acetylacetonate 叔丁基过氧化氢 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 363.0h， 生成 2-Hydroxymethyl-2-nonyloxirane
  参考文献：
  名称：

  Enzymic resolution of 2-substituted oxiranemethanols, a class of synthetically useful building blocks, bearing a chiral quaternary center

  摘要：

  DOI：

  10.1021/jo00018a057

文献信息

• Floerke, Holger; Schaumann, Ernst, Liebigs Annalen, 1996, # 1, p. 147 - 152
  作者：Floerke, Holger、Schaumann, Ernst

  DOI：——

  日期：——
• TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：EP2166843A2

  公开（公告）日：2010-03-31
• ANTI-VIRAL COMBINATION THERAPY
  申请人：THE TRUSTEES OF PRINCETON UNIVERSITY

  公开号：EP2725902A2

  公开（公告）日：2014-05-07
• [EN] TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS<br/>[FR] TRAITEMENT D'INFECTIONS VIRALES PAR MODULATION DE VOIES MÉTABOLIQUES DE CELLULES HÔTES
  申请人：UNIV PRINCETON

  公开号：WO2009023059A2

  公开（公告）日：2009-02-19

  Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in 'suicide' of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
• [EN] ANTI-VIRAL COMBINATION THERAPY<br/>[FR] POLYTHÉRAPIE ANTIVIRALE
  申请人：UNIV PRINCETON

  公开号：WO2012139028A2

  公开（公告）日：2012-10-11

  The present invention provides methods and compounds for treating viral infections using combinations modulators of an HCV-associated component and modulators of host cell enzymes. The present invention also provides methods and compounds for treating viral infections using combinations of modulators of host cell enzymes and other agents that work, at least in part by modulating host factors.