(2S)-3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxoacetylamino]propionic acid methyl ester | 1257308-31-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxoacetylamino]propionic acid methyl ester
• 英文别名: 3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]propionic acid methyl ester；3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxoacetylamino]propionic acid methyl ester；methyl (2-(1H-indol-3-yl)-2-oxoacetyl)tryptophanate；methyl (2S)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-2-oxoacetyl]amino]propanoate
• CAS: 1257308-31-8
• 化学式: C₂₂H₁₉N₃O₄
• 分子量: 389.411
• InChiKey: HIFDOUATSGPYEI-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S)-3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxoacetylamino]propionic acid methyl ester 在 盐酸 、 水 、 溶剂黄146 作用下， 反应 2.0h， 生成 (2S)-3-(1H-indol-3-yl)-2-[[2-(1H-indol-3-yl)-2-oxoacetyl]amino]propanoic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents

  摘要：

  A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC(50) value of 5.17 mu M and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.119
• 作为产物：
  描述：

  吲哚 在 potassium carbonate 作用下， 以 乙醚 、 乙腈 为溶剂， 生成 (2S)-3-(1H-indol-3-yl)-2-[2-(1H-indol-3-yl)-2-oxoacetylamino]propionic acid methyl ester
  参考文献：
  名称：

  Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent

  摘要：

  通过将氨基酸和三唑与吲哚基团进行嫁接构建的化合物已合成并用于抗真菌活性研究，其中一种化合物表现出非常有前景的结果。

  DOI：

  10.1039/c5md00156k

文献信息

• Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent
  作者：Kalpana Pawar、Anshuman Yadav、Parteek Prasher、Sahil Mishra、Balwinder Singh、Palwinder Singh、Sneha Sudha Komath

  DOI：10.1039/c5md00156k

  日期：——

  Compounds constructed by the grafting of amino acid and triazole with an indole moiety were synthesized and investigated for antifungal activities wherein one of the compounds gave highly promising results.

  通过将氨基酸和三唑与吲哚基团进行嫁接构建的化合物已合成并用于抗真菌活性研究，其中一种化合物表现出非常有前景的结果。
• Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes
  作者：Palwinder Singh、Parteek Prasher、Parvirti Dhillon、Rajbir Bhatti

  DOI：10.1016/j.ejmech.2015.04.044

  日期：2015.6

  The indoles bearing a tosyl group at N-1 and a dipeptide substituent at C-3 were screened for anti-inflammatory and anti-hyperalgesic activities. Some of the compounds made significant reduction in the dextran induced swelling and capsaicin induced pain in the albino mice. About 95% reversal in capsaicin induced pain occurred in the presence of 5 mg kg(-1) of compound 7b, 7d and 7h while diclofenac showed 90% reversal when its 10 mg kg(-1) dose was used. In order to examine the mode of action of these compounds; COX-1, COX-2 and 5-LOX enzyme immunoassays were performed. The IC50 of compound 7b for COX-2 and 5-LOX were in the nM range: 5-LOX, IC50 = 2.0 nM; COX-2, IC50 = 6.3 nM, selectivity for COX-2 over COX-1 was 351. The interactions of the compounds with COX-2 and 5-LOX were supported by the physical parameters including K-i, K-a and Delta G. The most potent compounds 7b, 7d and 7h showed no toxicity to the animals and were identified as the promising leads for anti-inflammatory drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.
• Lead modification: Amino acid appended indoles as highly effective 5-LOX inhibitors
  作者：Parteek Prasher、Pooja、Palwinder Singh

  DOI：10.1016/j.bmc.2014.01.027

  日期：2014.3

  N-1 tosyl indoles carrying amino acid as a part of C-3 substituent are identified with considerable 5-LOX inhibitory activities. On the basis of enzyme inhibitory activities and log P, it is found that these compounds are more suitable to use as ester prodrugs. In addition to the significant K-a and K-i for 5-LOX, advantageously the compounds under present investigation do not affect the viability of the cell. The experimental results were also supported by molecular docking of compounds in the active site of 5-LOX. (C) 2014 Elsevier Ltd. All rights reserved.
• Rational modification of a lead molecule: Improving the antifungal activity of indole – triazole – amino acid conjugates
  作者：Sahil Mishra、Manpreet Kaur、Subhash Chander、Sankaranarayanan Murugesan、Lovedeep Nim、D.S. Arora、Palwinder Singh

  DOI：10.1016/j.ejmech.2018.06.039

  日期：2018.7

  The modification of a molecule that was identified as highly efficacious in the previous studies could considerably improve the biological activity of the resulting compounds. While targeting lanosterol 14-alpha demethylase, the molecular modelling studies convinced that the extension of the phenyl ring of compound 1 deep into the hydrophobic pocket of the enzyme may increase the enzyme ligand interactions and hence improve the anti-fungal profile of the molecules. As a result, the newly designed compounds 2 were synthesized and screened for their anti-microbial properties and these compounds were found to exhibit considerably better activity than the previous molecule 1. Some of the compounds in this series exhibited MIC90 16 mu g mL(-1) and 32 mu g mL(-1) against Candida albicans and Aspergillus niger, respectively as against 312 mu g mL(-1) for compound 1. (C) 2018 Elsevier Masson SAS. All rights reserved.
• Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents
  作者：Shikha S. Chauhan、Leena Gupta、Monika Mittal、Preeti Vishwakarma、Suman Gupta、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2010.08.119

  日期：2010.11

  A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC(50) value of 5.17 mu M and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine. (C) 2010 Elsevier Ltd. All rights reserved.